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Long-term plasticity in hippocampal place-cell representation of environmental geometry

Author

Listed:
  • Colin Lever

    (University College London)

  • Tom Wills

    (University College London)

  • Francesca Cacucci

    (University College London)

  • Neil Burgess

    (University College London
    Institute of Cognitive Neuroscience, University College London)

  • John O'Keefe

    (University College London
    Institute of Cognitive Neuroscience, University College London)

Abstract

The hippocampus is widely believed to be involved in the storage or consolidation of long-term memories1,2,3,4. Several reports have shown short-term changes in single hippocampal unit activity during memory and plasticity experiments5,6,7,8,9,10,11,12, but there has been no experimental demonstration of long-term persistent changes in neuronal activity in any region except primary cortical areas13,14,15,16. Here we report that, in rats repeatedly exposed to two differently shaped environments, the hippocampal-place-cell representations of those environments gradually and incrementally diverge; this divergence is specific to environmental shape, occurs independently of explicit reward, persists for periods of at least one month, and transfers to new enclosures of the same shape. These results indicate that place cells may be a neural substrate for long-term incidental learning, and demonstrate the long-term stability of an experience-dependent firing pattern in the hippocampal formation.

Suggested Citation

  • Colin Lever & Tom Wills & Francesca Cacucci & Neil Burgess & John O'Keefe, 2002. "Long-term plasticity in hippocampal place-cell representation of environmental geometry," Nature, Nature, vol. 416(6876), pages 90-94, March.
    • Handle: RePEc:nat:nature:v:416:y:2002:i:6876:d:10.1038_416090a
    DOI: 10.1038/416090a
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    Cited by:

    1. Yi-Fan Zeng & Ke-Xin Yang & Yilong Cui & Xiao-Na Zhu & Rui Li & Hanqing Zhang & Dong Chuan Wu & Raymond C. Stevens & Ji Hu & Ning Zhou, 2024. "Conjunctive encoding of exploratory intentions and spatial information in the hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Yanjun Sun & Lisa M. Giocomo, 2022. "Neural circuit dynamics of drug-context associative learning in the mouse hippocampus," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Yung-Tian A. Gau & Eric T. Hsu & Richard J. Cha & Rebecca W. Pak & Loren L. Looger & Jin U. Kang & Dwight E. Bergles, 2024. "Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    4. Dino Dvorak & Basma Radwan & Fraser T Sparks & Zoe Nicole Talbot & André A Fenton, 2018. "Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1," PLOS Biology, Public Library of Science, vol. 16(1), pages 1-27, January.
    5. Carina Curto & Vladimir Itskov, 2008. "Cell Groups Reveal Structure of Stimulus Space," PLOS Computational Biology, Public Library of Science, vol. 4(10), pages 1-13, October.

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