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Functional neurogenesis in the adult hippocampus

Author

Listed:
  • Henriette van Praag

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Alejandro F. Schinder

    (Laboratory of Genetics, The Salk Institute for Biological Studies
    Instituto de Investigaciones Bioquímicas Fundación Campomar)

  • Brian R. Christie

    (Laboratory of Genetics, The Salk Institute for Biological Studies
    University of British Columbia Vancouver)

  • Nicolas Toni

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Theo D. Palmer

    (Laboratory of Genetics, The Salk Institute for Biological Studies
    Stanford University)

  • Fred H. Gage

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

Abstract

There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory1,2,3,4,5. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.

Suggested Citation

  • Henriette van Praag & Alejandro F. Schinder & Brian R. Christie & Nicolas Toni & Theo D. Palmer & Fred H. Gage, 2002. "Functional neurogenesis in the adult hippocampus," Nature, Nature, vol. 415(6875), pages 1030-1034, February.
    • Handle: RePEc:nat:nature:v:415:y:2002:i:6875:d:10.1038_4151030a
    DOI: 10.1038/4151030a
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    Cited by:

    1. James O Groves & Isla Leslie & Guo-Jen Huang & Stephen B McHugh & Amy Taylor & Richard Mott & Marcus Munafò & David M Bannerman & Jonathan Flint, 2013. "Ablating Adult Neurogenesis in the Rat Has No Effect on Spatial Processing: Evidence from a Novel Pharmacogenetic Model," PLOS Genetics, Public Library of Science, vol. 9(9), pages 1-16, September.
    2. Wen-Chung Liu & Chih-Wei Wu & Pi-Lien Hung & Julie Y. H. Chan & You-Lin Tain & Mu-Hui Fu & Lee-Wei Chen & Chih-Kuang Liang & Chun-Ying Hung & Hong-Ren Yu & I-Chun Chen & Kay L.H. Wu, 2020. "Environmental Stimulation Counteracts the Suppressive Effects of Maternal High-Fructose Diet on Cell Proliferation and Neuronal Differentiation in the Dentate Gyrus of Adult Female Offspring via Histo," IJERPH, MDPI, vol. 17(11), pages 1-15, June.
    3. Kai Diederich & Wolf-Rüdiger Schäbitz & Katharina Kuhnert & Nina Hellström & Norbert Sachser & Armin Schneider & Hans-Georg Kuhn & Stefan Knecht, 2009. "Synergetic Effects of Granulocyte-Colony Stimulating Factor and Cognitive Training on Spatial Learning and Survival of Newborn Hippocampal Neurons," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-7, April.
    4. Lucas A Mongiat & M Soledad Espósito & Gabriela Lombardi & Alejandro F Schinder, 2009. "Reliable Activation of Immature Neurons in the Adult Hippocampus," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-11, April.

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