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Reprogramming of genome function through epigenetic inheritance

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  • M. Azim Surani

    (Wellcome CRC Institute of Cancer and Developmental Biology, and Physiological Laboratory, University of Cambridge)

Abstract

Most cells contain the same set of genes and yet they are extremely diverse in appearance and functions. It is the selective expression and repression of genes that determines the specific properties of individual cells. Nevertheless, even when fully differentiated, any cell can potentially be reprogrammed back to totipotency, which in turn results in re-differentiation of the full repertoire of adult cells from a single original cell of any kind. Mechanisms that regulate this exceptional genomic plasticity and the state of totipotency are being unravelled, and will enhance our ability to manipulate stem cells for therapeutic purposes.

Suggested Citation

  • M. Azim Surani, 2001. "Reprogramming of genome function through epigenetic inheritance," Nature, Nature, vol. 414(6859), pages 122-128, November.
    • Handle: RePEc:nat:nature:v:414:y:2001:i:6859:d:10.1038_35102186
    DOI: 10.1038/35102186
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    Cited by:

    1. Awny Naim & Hedaya Al Dalies & Mohammed El Balawi & Eman Salem & Kholud Al Meziny & Raneem Al Shawwa & Roberto Minutolo & Paola Manduca, 2012. "Birth Defects in Gaza: Prevalence, Types, Familiarity and Correlation with Environmental Factors," IJERPH, MDPI, vol. 9(5), pages 1-16, May.
    2. M. Samiec & M. Skrzyszowska, 2005. "Molecular conditions of the cell nucleus remodelling/reprogramming process and nuclear-transferred embryo development in the intraooplasmic karyoplast injection technique: a review," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 50(5), pages 185-195.
    3. Samira Alaani & Mozhgan Savabieasfahani & Mohammad Tafash & Paola Manduca, 2010. "Four Polygamous Families with Congenital Birth Defects from Fallujah, Iraq," IJERPH, MDPI, vol. 8(1), pages 1-8, December.

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