IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v414y2001i6859d10.1038_35102186.html
   My bibliography  Save this article

Reprogramming of genome function through epigenetic inheritance

Author

Listed:
  • M. Azim Surani

    (Wellcome CRC Institute of Cancer and Developmental Biology, and Physiological Laboratory, University of Cambridge)

Abstract

Most cells contain the same set of genes and yet they are extremely diverse in appearance and functions. It is the selective expression and repression of genes that determines the specific properties of individual cells. Nevertheless, even when fully differentiated, any cell can potentially be reprogrammed back to totipotency, which in turn results in re-differentiation of the full repertoire of adult cells from a single original cell of any kind. Mechanisms that regulate this exceptional genomic plasticity and the state of totipotency are being unravelled, and will enhance our ability to manipulate stem cells for therapeutic purposes.

Suggested Citation

  • M. Azim Surani, 2001. "Reprogramming of genome function through epigenetic inheritance," Nature, Nature, vol. 414(6859), pages 122-128, November.
    • Handle: RePEc:nat:nature:v:414:y:2001:i:6859:d:10.1038_35102186
    DOI: 10.1038/35102186
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35102186
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35102186?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. M. Samiec & M. Skrzyszowska, 2005. "Molecular conditions of the cell nucleus remodelling/reprogramming process and nuclear-transferred embryo development in the intraooplasmic karyoplast injection technique: a review," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 50(5), pages 185-195.
    2. Samira Alaani & Mozhgan Savabieasfahani & Mohammad Tafash & Paola Manduca, 2010. "Four Polygamous Families with Congenital Birth Defects from Fallujah, Iraq," IJERPH, MDPI, vol. 8(1), pages 1-8, December.
    3. Awny Naim & Hedaya Al Dalies & Mohammed El Balawi & Eman Salem & Kholud Al Meziny & Raneem Al Shawwa & Roberto Minutolo & Paola Manduca, 2012. "Birth Defects in Gaza: Prevalence, Types, Familiarity and Correlation with Environmental Factors," IJERPH, MDPI, vol. 9(5), pages 1-16, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:414:y:2001:i:6859:d:10.1038_35102186. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.