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Complete genome sequence of Salmonella enterica serovar Typhimurium LT2

Author

Listed:
  • Michael McClelland

    (Sidney Kimmel Cancer Center)

  • Kenneth E. Sanderson

    (University of Calgary)

  • John Spieth

    (Genome Sequencing Center, Washington University School of Medicine)

  • Sandra W. Clifton

    (Genome Sequencing Center, Washington University School of Medicine)

  • Phil Latreille

    (Genome Sequencing Center, Washington University School of Medicine)

  • Laura Courtney

    (Genome Sequencing Center, Washington University School of Medicine)

  • Steffen Porwollik

    (Sidney Kimmel Cancer Center)

  • Johar Ali

    (Genome Sequencing Center, Washington University School of Medicine)

  • Mike Dante

    (Genome Sequencing Center, Washington University School of Medicine)

  • Feiyu Du

    (Genome Sequencing Center, Washington University School of Medicine)

  • Shunfang Hou

    (Genome Sequencing Center, Washington University School of Medicine)

  • Dan Layman

    (Genome Sequencing Center, Washington University School of Medicine)

  • Shawn Leonard

    (Genome Sequencing Center, Washington University School of Medicine)

  • Christine Nguyen

    (Genome Sequencing Center, Washington University School of Medicine)

  • Kelsi Scott

    (Genome Sequencing Center, Washington University School of Medicine)

  • Andrea Holmes

    (Genome Sequencing Center, Washington University School of Medicine)

  • Neenu Grewal

    (Genome Sequencing Center, Washington University School of Medicine)

  • Elizabeth Mulvaney

    (Genome Sequencing Center, Washington University School of Medicine)

  • Ellen Ryan

    (Genome Sequencing Center, Washington University School of Medicine)

  • Hui Sun

    (Genome Sequencing Center, Washington University School of Medicine)

  • Liliana Florea

    (The Pennsylvania State University
    Celera Genomics)

  • Webb Miller

    (The Pennsylvania State University)

  • Tamberlyn Stoneking

    (Genome Sequencing Center, Washington University School of Medicine)

  • Michael Nhan

    (Genome Sequencing Center, Washington University School of Medicine)

  • Robert Waterston

    (Genome Sequencing Center, Washington University School of Medicine)

  • Richard K. Wilson

    (Genome Sequencing Center, Washington University School of Medicine)

Abstract

Salmonella enterica subspecies I, serovar Typhimurium (S. typhimurium), is a leading cause of human gastroenteritis, and is used as a mouse model of human typhoid fever1. The incidence of non-typhoid salmonellosis is increasing worldwide2,3,4, causing millions of infections and many deaths in the human population each year. Here we sequenced the 4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain LT2. The distribution of close homologues of S. typhimurium LT2 genes in eight related enterobacteria was determined using previously completed genomes of three related bacteria, sample sequencing of both S. enterica serovar Paratyphi A (S. paratyphi A) and Klebsiella pneumoniae, and hybridization of three unsequenced genomes to a microarray of S. typhimurium LT2 genes. Lateral transfer of genes is frequent, with 11% of the S. typhimurium LT2 genes missing from S. enterica serovar Typhi (S. typhi), and 29% missing from Escherichia coli K12. The 352 gene homologues of S. typhimurium LT2 confined to subspecies I of S. enterica—containing most mammalian and bird pathogens5—are useful for studies of epidemiology, host specificity and pathogenesis. Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering them accessible as therapeutic or vaccine targets.

Suggested Citation

  • Michael McClelland & Kenneth E. Sanderson & John Spieth & Sandra W. Clifton & Phil Latreille & Laura Courtney & Steffen Porwollik & Johar Ali & Mike Dante & Feiyu Du & Shunfang Hou & Dan Layman & Shaw, 2001. "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2," Nature, Nature, vol. 413(6858), pages 852-856, October.
    • Handle: RePEc:nat:nature:v:413:y:2001:i:6858:d:10.1038_35101614
    DOI: 10.1038/35101614
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    Cited by:

    1. Ying Xiang & Kunpeng Zhu & Kaiyuan Min & Yaowen Zhang & Jiangfeng Liu & Kangkang Liu & Yiran Han & Xinge Li & Xinying Du & Xin Wang & Ying Huang & Xinping Li & Yuqian Peng & Chaojie Yang & Hongbo Liu , 2024. "Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Nanna Munck & Patrick Murigu Kamau Njage & Pimlapas Leekitcharoenphon & Eva Litrup & Tine Hald, 2020. "Application of Whole‐Genome Sequences and Machine Learning in Source Attribution of Salmonella Typhimurium," Risk Analysis, John Wiley & Sons, vol. 40(9), pages 1693-1705, September.
    3. Yu-Yu Cheng & Zhengyi Chen & Xinyun Cao & Tyler D. Ross & Tanya G. Falbel & Briana M. Burton & Ophelia S. Venturelli, 2023. "Programming bacteria for multiplexed DNA detection," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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