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B cells acquire antigen from target cells after synapse formation

Author

Listed:
  • Facundo D. Batista

    (Medical Research Laboratory of Molecular Biology)

  • Dagmar Iber

    (Medical Research Laboratory of Molecular Biology)

  • Michael S. Neuberger

    (Medical Research Laboratory of Molecular Biology)

Abstract

Soluble antigen binds to the B-cell antigen receptor and is internalized for subsequent processing and the presentation of antigen-derived peptides to T cells1. Many antigens are not soluble, however, but are integral components of membrane; furthermore, soluble antigens will usually be encountered in vivo in a membrane-anchored form, tethered by Fc or complement receptors2,3,4. Here we show that B-cell interaction with antigens that are immobilized on the surface of a target cell leads to the formation of a synapse and the acquisition, even, of membrane-integral antigens from the target. B-cell antigen receptor accumulates at the synapse, segregated from the CD45 co-receptor which is excluded from the synapse, and there is a corresponding polarization of cytoplasmic effectors in the B cell. B-cell antigen receptor mediates the gathering of antigen into the synapse and its subsequent acquisition, thereby potentiating antigen processing and presentation to T cells with high efficacy. Synapse formation and antigen acquisition will probably enhance the activation of B cells at low antigen concentration, allow context-dependent antigen recognition and enhance the linking of B- and T-cell epitopes.

Suggested Citation

  • Facundo D. Batista & Dagmar Iber & Michael S. Neuberger, 2001. "B cells acquire antigen from target cells after synapse formation," Nature, Nature, vol. 411(6836), pages 489-494, May.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6836:d:10.1038_35078099
    DOI: 10.1038/35078099
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    Cited by:

    1. Eike-Christian Wamhoff & Larance Ronsard & Jared Feldman & Grant A. Knappe & Blake M. Hauser & Anna Romanov & James Brett Case & Shilpa Sanapala & Evan C. Lam & Kerri J. St. Denis & Julie Boucau & Amy, 2024. "Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Hassan N. Althurwi & Khalid M. Alharthy & Faisal F. Albaqami & Ali Altharawi & Muhammad Rizwan Javed & Ziyad Tariq Muhseen & Muhammad Tahir ul Qamar, 2022. "mRNA-Based Vaccine Designing against Epstein-Barr Virus to Induce an Immune Response Using Immunoinformatic and Molecular Modelling Approaches," IJERPH, MDPI, vol. 19(20), pages 1-21, October.
    3. Jonathan D. Worboys & Katherine N. Vowell & Roseanna K. Hare & Ashley R. Ambrose & Margherita Bertuzzi & Michael A. Conner & Florence P. Patel & William H. Zammit & Judit Gali-Moya & Khodor S. Hazime , 2023. "TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Julia Merkenschlager & Riza-Maria Berz & Victor Ramos & Maximilian Uhlig & Andrew J. MacLean & Carla R. Nowosad & Thiago Y. Oliveira & Michel C. Nussenzweig, 2023. "Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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