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Mammalian MAP kinase signalling cascades

Author

Listed:
  • Lufen Chang

    (University of California San Diego)

  • Michael Karin

    (University of California San Diego)

Abstract

Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death.

Suggested Citation

  • Lufen Chang & Michael Karin, 2001. "Mammalian MAP kinase signalling cascades," Nature, Nature, vol. 410(6824), pages 37-40, March.
    • Handle: RePEc:nat:nature:v:410:y:2001:i:6824:d:10.1038_35065000
    DOI: 10.1038/35065000
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    Cited by:

    1. Raffaele Pezzilli & Antonio M. Morselli-Labate, 2009. "Alcoholic Pancreatitis: Pathogenesis, Incidence and Treatment with Special Reference to the Associated Pain," IJERPH, MDPI, vol. 6(11), pages 1-20, November.
    2. Chih-Chien Wang & Chih-Yun Huang & Meng-Chang Lee & Dung-Jang Tsai & Chia-Chun Wu & Sui-Lung Su, 2021. "Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-15, November.
    3. Jason W Locasale & Arup K Chakraborty, 2008. "Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins," PLOS Computational Biology, Public Library of Science, vol. 4(6), pages 1-12, June.
    4. Kazunari Iwamoto & Yuki Shindo & Koichi Takahashi, 2016. "Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway," PLOS Computational Biology, Public Library of Science, vol. 12(11), pages 1-18, November.
    5. Lina Chen & Wan Li & Liangcai Zhang & Hong Wang & Weiming He & Jingxie Tai & Xu Li & Xia Li, 2011. "Disease Gene Interaction Pathways: A Potential Framework for How Disease Genes Associate by Disease-Risk Modules," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-12, September.
    6. Xubin Lu & Hui Jiang & Abdelaziz Adam Idriss Arbab & Bo Wang & Dingding Liu & Ismail Mohamed Abdalla & Tianle Xu & Yujia Sun & Zongping Liu & Zhangping Yang, 2023. "Investigating Genetic Characteristics of Chinese Holstein Cow’s Milk Somatic Cell Score by Genetic Parameter Estimation and Genome-Wide Association," Agriculture, MDPI, vol. 13(2), pages 1-17, January.
    7. Hany A Omar & Wafaa R Mohamed & Hany H Arab & El-Shaimaa A Arafa, 2016. "Tangeretin Alleviates Cisplatin-Induced Acute Hepatic Injury in Rats: Targeting MAPKs and Apoptosis," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-18, March.
    8. Xiaocui Chen & Jing Li & Zuowang Cheng & Yinghua Xu & Xia Wang & Xiaorui Li & Dongmei Xu & Carolyn M. Kapron & Ju Liu, 2016. "Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells via Activation of the JNK Pathway," IJERPH, MDPI, vol. 13(10), pages 1-12, October.
    9. Thomas C Whisenant & David T Ho & Ryan W Benz & Jeffrey S Rogers & Robyn M Kaake & Elizabeth A Gordon & Lan Huang & Pierre Baldi & Lee Bardwell, 2010. "Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors," PLOS Computational Biology, Public Library of Science, vol. 6(8), pages 1-21, August.
    10. Christopher C Govern & Arup K Chakraborty, 2009. "Signaling Cascades Modulate the Speed of Signal Propagation through Space," PLOS ONE, Public Library of Science, vol. 4(2), pages 1-7, February.
    11. Luca Marchetti & Rosario Lombardo & Corrado Priami, 2017. "HSimulator: Hybrid Stochastic/Deterministic Simulation of Biochemical Reaction Networks," Complexity, Hindawi, vol. 2017, pages 1-12, December.
    12. Peter Rashkov & Ian P Barrett & Robert E Beardmore & Claus Bendtsen & Ivana Gudelj, 2016. "Kinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation Cycle," PLOS Computational Biology, Public Library of Science, vol. 12(11), pages 1-15, November.
    13. Aysegul Yildiz & Ozgur Tanriverdi, 2017. "MAPK and AKT Pathway Intersection in Neuroblastoma Cells," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 2(1), pages 17-20, March.
    14. Satoya Yoshida & Tatsuya Yoshida & Kohei Inukai & Katsuhiro Kato & Yoshimitsu Yura & Tomoki Hattori & Atsushi Enomoto & Koji Ohashi & Takahiro Okumura & Noriyuki Ouchi & Haruya Kawase & Nina Wettschur, 2024. "Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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