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Learning about addiction from the genome

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  • Eric J. Nestler

    (The University of Texas Southwestern Medical Center)

  • David Landsman

    (National Center for Biotechnology Information, National Library of Medicine, Computational Biology Branch, Building 45, Room 6AN12J)

Abstract

Drug addiction can be defined as the compulsive seeking and taking of a drug despite adverse consequences. Although addiction involves many psychological and social factors, it also represents a biological process: the effects of repeated drug exposure on a vulnerable brain. The sequencing of the human and other mammalian genomes will help us to understand the biology of addiction by enabling us to identify both genes that contribute to individual risk for addiction and those through which drugs cause addiction. We illustrate this potential impact by searching a draft sequence of the human genome for genes related to desensitization of receptors that mediate the actions of drugs of abuse on the nervous system.

Suggested Citation

  • Eric J. Nestler & David Landsman, 2001. "Learning about addiction from the genome," Nature, Nature, vol. 409(6822), pages 834-835, February.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6822:d:10.1038_35057015
    DOI: 10.1038/35057015
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    Cited by:

    1. Steve Sussman & Adam Leventhal & Ricky N. Bluthenthal & Marilyn Freimuth & Myriam Forster & Susan L. Ames, 2011. "A Framework for the Specificity of Addictions," IJERPH, MDPI, vol. 8(8), pages 1-17, August.

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