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The DNA damage response: putting checkpoints in perspective

Author

Listed:
  • Bin-Bing S. Zhou

    (Department of Oncology Research SmithKline Beecham Pharmaceuticals)

  • Stephen J. Elledge

    (Howard Hughes Medical Institute, Baylor College of Medicine)

Abstract

The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.

Suggested Citation

  • Bin-Bing S. Zhou & Stephen J. Elledge, 2000. "The DNA damage response: putting checkpoints in perspective," Nature, Nature, vol. 408(6811), pages 433-439, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6811:d:10.1038_35044005
    DOI: 10.1038/35044005
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    Cited by:

    1. Daekyu Sun & John Michael White, 2017. "Potential Mechanism of Chemo-Resistance to Gemcitabine," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(3), pages 50-53, August.
    2. Sarasa Isobe & Ramesh V. Nair & Helen Y. Kang & Lingli Wang & Jan-Renier Moonen & Tsutomu Shinohara & Aiqin Cao & Shalina Taylor & Shoichiro Otsuki & David P. Marciano & Rebecca L. Harper & Mir S. Adi, 2023. "Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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