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Genetic pathways that regulate ageing in model organisms

Author

Listed:
  • Leonard Guarente

    (Massachusetts Institute of Technology)

  • Cynthia Kenyon

    (University of California at San Francisco)

Abstract

Searches for genes involved in the ageing process have been made in genetically tractable model organisms such as yeast, the nematode Caenorhabditis elegans , Drosophila melanogaster fruitflies and mice. These genetic studies have established that ageing is indeed regulated by specific genes, and have allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation. Intriguing similarities in the phenotypes of many of these mutants indicate that the mutations may also perturb regulatory systems that control ageing in higher organisms.

Suggested Citation

  • Leonard Guarente & Cynthia Kenyon, 2000. "Genetic pathways that regulate ageing in model organisms," Nature, Nature, vol. 408(6809), pages 255-262, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6809:d:10.1038_35041700
    DOI: 10.1038/35041700
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    Cited by:

    1. Yan-Ping Zhang & Wen-Hong Zhang & Pan Zhang & Qi Li & Yue Sun & Jia-Wen Wang & Shaobing O. Zhang & Tao Cai & Cheng Zhan & Meng-Qiu Dong, 2022. "Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Alan A Cohen & Emmanuel Milot & Qing Li & Patrick Bergeron & Roxane Poirier & Francis Dusseault-Bélanger & Tamàs Fülöp & Maxime Leroux & Véronique Legault & E Jeffrey Metter & Linda P Fried & Luigi Fe, 2015. "Detection of a Novel, Integrative Aging Process Suggests Complex Physiological Integration," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-26, March.

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