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The age of cancer

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  • Ronald A. DePinho

    (Medicine and Genetics Dana-Farber Cancer Institute, Harvard Medical School)

Abstract

A striking link exists between advanced age and increased incidence of cancer. Here I review how several of the age-related molecular and physiological changes might act in concert to promote cancer, and in particular epithelial carcinogenesis. Experimental data indicate that the aged, cancer-prone phenotype might represent the combined pathogenetic effects of mutation load, epigenetic regulation, telomere dysfunction and altered stromal milieu. Further verification of the role of these effects should in turn lead to the design of effective therapeutics for the treatment and prevention of cancer in the aged.

Suggested Citation

  • Ronald A. DePinho, 2000. "The age of cancer," Nature, Nature, vol. 408(6809), pages 248-254, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6809:d:10.1038_35041694
    DOI: 10.1038/35041694
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    Cited by:

    1. Leuven, Edwin & Plug, Erik & Rønning, Marte, 2016. "Education and cancer risk," Labour Economics, Elsevier, vol. 43(C), pages 106-121.
    2. Janina Nemitz, 2022. "Increasing longevity and life satisfaction: is there a catch to living longer?," Journal of Population Economics, Springer;European Society for Population Economics, vol. 35(2), pages 557-589, April.
    3. Svetlana Ukraintseva & Anatoli Yashin, 2003. "Individual Aging and Cancer Risk: How are They Related?," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 9(8), pages 163-196.

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