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Molecular mechanisms that confer antibacterial drug resistance

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  • Christopher Walsh

    (Biological Chemistry and Molecular Pharmacology Department Harvard Medical School)

Abstract

Antibiotics — compounds that are literally ‘against life’ — are typically antibacterial drugs, interfering with some structure or process that is essential to bacterial growth or survival without harm to the eukaryotic host harbouring the infecting bacteria. We live in an era when antibiotic resistance has spread at an alarming rate1,2,3,4 and when dire predictions concerning the lack of effective antibacterial drugs occur with increasing frequency. In this context it is apposite to ask a few simple questions about these life-saving molecules. What are antibiotics? Where do they come from? How do they work? Why do they stop being effective? How do we find new antibiotics? And can we slow down the development of antibiotic-resistant superbugs?

Suggested Citation

  • Christopher Walsh, 2000. "Molecular mechanisms that confer antibacterial drug resistance," Nature, Nature, vol. 406(6797), pages 775-781, August.
    • Handle: RePEc:nat:nature:v:406:y:2000:i:6797:d:10.1038_35021219
    DOI: 10.1038/35021219
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    Cited by:

    1. Jianping Li & Ampon Sae Her & Alida Besch & Belen Ramirez-Cordero & Maureen Crames & James R. Banigan & Casey Mueller & William M. Marsiglia & Yingkai Zhang & Nathaniel J. Traaseth, 2024. "Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Ifeanyi A. Onwuezobe* & Ubong E. Etang, 2018. "Current Antibiotic Resistance Trends of Uropathogens from Outpatients in a Nigerian Urban Health Care Facility," International Journal of Healthcare and Medical Sciences, Academic Research Publishing Group, vol. 4(6), pages 99-104, 06-2018.
    3. Jin Feng & Youle Zheng & Wanqing Ma & Defeng Weng & Dapeng Peng & Yindi Xu & Zhifang Wang & Xu Wang, 2024. "A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Eremwanarue Aibuedefe Osagie & Shittu Hakeem Olalekan & Eremwanarue Aibuedefe Osagie, 2019. "Multiple Drug Resistance- A Fast-Growing Threat," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 21(2), pages 15715-15726, September.
    5. Dmitry Leshchiner & Federico Rosconi & Bharathi Sundaresh & Emily Rudmann & Luisa Maria Nieto Ramirez & Andrew T. Nishimoto & Stephen J. Wood & Bimal Jana & Noemí Buján & Kaicheng Li & Jianmin Gao & M, 2022. "A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Zhengyan Guo & Yao Yao & Yuan-Cheng Chang, 2022. "Research on Customer Behavioral Intention of Hot Spring Resorts Based on SOR Model: The Multiple Mediation Effects of Service Climate and Employee Engagement," Sustainability, MDPI, vol. 14(14), pages 1-15, July.
    7. Pavan Gollapalli, 2017. "Anti-Evolutionary Targets in Bacterial Efflux Pumps Future Therapeutics to Combat Antibacterial Resistance," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 1(5), pages 109-110, February.
    8. Jody L. Andersen & Gui-Xin He & Prathusha Kakarla & Ranjana KC & Sanath Kumar & Wazir Singh Lakra & Mun Mun Mukherjee & Indrika Ranaweera & Ugina Shrestha & Thuy Tran & Manuel F. Varela, 2015. "Multidrug Efflux Pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus Bacterial Food Pathogens," IJERPH, MDPI, vol. 12(2), pages 1-61, January.

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