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Roles of PPARs in health and disease

Author

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  • Sander Kersten

    (Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne)

  • Béatrice Desvergne

    (Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne)

  • Walter Wahli

    (Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne)

Abstract

In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in these diseases. This, together with the fact that PPAR activity can be modulated by drugs such as thiazolidinediones and fibrates, has instigated a huge research effort into PPARs1. Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.

Suggested Citation

  • Sander Kersten & Béatrice Desvergne & Walter Wahli, 2000. "Roles of PPARs in health and disease," Nature, Nature, vol. 405(6785), pages 421-424, May.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6785:d:10.1038_35013000
    DOI: 10.1038/35013000
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    Cited by:

    1. W. Wang & W. Xue & X. Xu & B. Jin & X. Zhang, 2016. "Correlations of genes expression in PPAR signalling pathway with porcine meat quality traits," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 61(7), pages 333-339.
    2. A. Aparicio-Cecilio & J. Bouda & E.G. Salgado-Hernández & L. Núñez-Ochoa & D.A. Castillo-Mata & A. Gutiérrez-Chávez, 2012. "Effect of 2-methyl-2-phenoxy propionic acid on serum lipid profile and ovarian activity in dairy cows," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 57(12), pages 550-556.
    3. Jun-Wei Gao & Ling Zeng & An-Qiang Zhang & Xiao Wang & Wei Pan & Ding-Yuan Du & Lian-Yang Zhang & Wei Gu & Jian-Xin Jiang, 2016. "Identification of Haplotype Tag Single-Nucleotide Polymorphisms within the PPAR Family Genes and Their Clinical Relevance in Patients with Major Trauma," IJERPH, MDPI, vol. 13(4), pages 1-11, March.
    4. Grazia Pennisi & Ciro Celsa & Federica Spatola & Marcello Dallio & Alessandro Federico & Salvatore Petta, 2019. "Pharmacological Therapy of Non-Alcoholic Fatty Liver Disease: What Drugs Are Available Now and Future Perspectives," IJERPH, MDPI, vol. 16(22), pages 1-26, November.

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