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Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

Author

Listed:
  • Carl-Philipp Heisenberg

    (University College London)

  • Masazumi Tada

    (Division of Developmental Biology National Institute for Medical Research)

  • Gerd-Jörg Rauch

    (Max-Planck-Institut für Entwicklungsbiologie)

  • Leonor Saúde

    (Division of Developmental Biology National Institute for Medical Research)

  • Miguel L. Concha

    (University College London)

  • Robert Geisler

    (Max-Planck-Institut für Entwicklungsbiologie)

  • Derek L. Stemple

    (Division of Developmental Biology National Institute for Medical Research)

  • James C. Smith

    (Division of Developmental Biology National Institute for Medical Research)

  • Stephen W. Wilson

    (University College London)

Abstract

Vertebrate gastrulation involves the specification and coordinated movement of large populations of cells that give rise to the ectodermal, mesodermal and endodermal germ layers. Although many of the genes involved in the specification of cell identity during this process have been identified, little is known of the genes that coordinate cell movement. Here we show that the zebrafish silberblick (slb) locus1 encodes Wnt11 and that Slb/Wnt11 activity is required for cells to undergo correct convergent extension movements during gastrulation. In the absence of Slb/Wnt11 function, abnormal extension of axial tissue results in cyclopia and other midline defects in the head2. The requirement for Slb/Wnt11 is cell non-autonomous, and our results indicate that the correct extension of axial tissue is at least partly dependent on medio-lateral cell intercalation in paraxial tissue. We also show that the slb phenotype is rescued by a truncated form of Dishevelled that does not signal through the canonical Wnt pathway3, suggesting that, as in flies4, Wnt signalling might mediate morphogenetic events through a divergent signal transduction cascade. Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation.

Suggested Citation

  • Carl-Philipp Heisenberg & Masazumi Tada & Gerd-Jörg Rauch & Leonor Saúde & Miguel L. Concha & Robert Geisler & Derek L. Stemple & James C. Smith & Stephen W. Wilson, 2000. "Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation," Nature, Nature, vol. 405(6782), pages 76-81, May.
  • Handle: RePEc:nat:nature:v:405:y:2000:i:6782:d:10.1038_35011068
    DOI: 10.1038/35011068
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    Cited by:

    1. Maria Jussila & Curtis W. Boswell & Nigel W. Griffiths & Patrick G. Pumputis & Brian Ciruna, 2022. "Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Ana Sousa-Ortega & Javier Vázquez-Marín & Estefanía Sanabria-Reinoso & Jorge Corbacho & Rocío Polvillo & Alejandro Campoy-López & Lorena Buono & Felix Loosli & María Almuedo-Castillo & Juan R. Martíne, 2023. "A Yap-dependent mechanoregulatory program sustains cell migration for embryo axis assembly," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Katarzyna Niescierowicz & Leszek Pryszcz & Cristina Navarrete & Eugeniusz Tralle & Agata Sulej & Karim Abu Nahia & Marta Elżbieta Kasprzyk & Katarzyna Misztal & Abhishek Pateria & Adrianna Pakuła & Ma, 2022. "Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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