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A Drosophila model of Parkinson's disease

Author

Listed:
  • Mel B. Feany

    (Brigham and Women's Hospital and Harvard Medical School and)

  • Welcome W. Bender

    (Harvard Medical School)

Abstract

Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the α-synuclein gene are linked to familial Parkinson's disease1,2 and α-synuclein accumulates in Lewy bodies and Lewy neurites3,4,5. Here we express normal and mutant forms of α-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing α-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease.

Suggested Citation

  • Mel B. Feany & Welcome W. Bender, 2000. "A Drosophila model of Parkinson's disease," Nature, Nature, vol. 404(6776), pages 394-398, March.
    • Handle: RePEc:nat:nature:v:404:y:2000:i:6776:d:10.1038_35006074
    DOI: 10.1038/35006074
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    Cited by:

    1. Sylvia Varland & Rui Duarte Silva & Ine Kjosås & Alexandra Faustino & Annelies Bogaert & Maximilian Billmann & Hadi Boukhatmi & Barbara Kellen & Michael Costanzo & Adrian Drazic & Camilla Osberg & Kat, 2023. "N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity," Nature Communications, Nature, vol. 14(1), pages 1-27, December.
    2. Laura Hermans & Murat Kaynak & Jonas Braun & Victor Lobato Ríos & Chin-Lin Chen & Adam Friedberg & Semih Günel & Florian Aymanns & Mahmut Selman Sakar & Pavan Ramdya, 2022. "Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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