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The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences

Author

Listed:
  • J. Parkhill

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • B. W. Wren

    (The London School of Hygiene and Tropical Medicine)

  • K. Mungall

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • J. M. Ketley

    (University of Leicester)

  • C. Churcher

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • D. Basham

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • T. Chillingworth

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • R. M. Davies

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • T. Feltwell

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • S. Holroyd

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • K. Jagels

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • A. V. Karlyshev

    (The London School of Hygiene and Tropical Medicine)

  • S. Moule

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • M. J. Pallen

    (Queen's University Belfast)

  • C. W. Penn

    (School of Biosciences, University of Birmingham)

  • M. A. Quail

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • M-A. Rajandream

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • K. M. Rutherford

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • A. H. M. van Vliet

    (Faculty of Medicine, Vrije Universiteit)

  • S. Whitehead

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

  • B. G. Barrell

    (The Sanger Centre, The Wellcome Trust Genome Campus, Hinxton)

Abstract

Campylobacter jejuni, from the delta-epsilon group of proteobacteria, is a microaerophilic, Gram-negative, flagellate, spiral bacterium—properties it shares with the related gastric pathogen Helicobacter pylori. It is the leading cause of bacterial food-borne diarrhoeal disease throughout the world1. In addition, infection with C. jejuni is the most frequent antecedent to a form of neuromuscular paralysis known as Guillain–Barré syndrome2. Here we report the genome sequence of C. jejuni NCTC11168. C. jejuni has a circular chromosome of 1,641,481 base pairs (30.6% G+C) which is predicted to encode 1,654 proteins and 54 stable RNA species. The genome is unusual in that there are virtually no insertion sequences or phage-associated sequences and very few repeat sequences. One of the most striking findings in the genome was the presence of hypervariable sequences. These short homopolymeric runs of nucleotides were commonly found in genes encoding the biosynthesis or modification of surface structures, or in closely linked genes of unknown function. The apparently high rate of variation of these homopolymeric tracts may be important in the survival strategy of C. jejuni.

Suggested Citation

  • J. Parkhill & B. W. Wren & K. Mungall & J. M. Ketley & C. Churcher & D. Basham & T. Chillingworth & R. M. Davies & T. Feltwell & S. Holroyd & K. Jagels & A. V. Karlyshev & S. Moule & M. J. Pallen & C., 2000. "The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences," Nature, Nature, vol. 403(6770), pages 665-668, February.
    • Handle: RePEc:nat:nature:v:403:y:2000:i:6770:d:10.1038_35001088
    DOI: 10.1038/35001088
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    Citations

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    Cited by:

    1. Martin Ackermann & Lin Chao, 2006. "DNA Sequences Shaped by Selection for Stability," PLOS Genetics, Public Library of Science, vol. 2(2), pages 1-7, February.
    2. Christopher Ruis & Aaron Weimann & Gerry Tonkin-Hill & Arun Prasad Pandurangan & Marta Matuszewska & Gemma G. R. Murray & Roger C. Lévesque & Tom L. Blundell & R. Andres Floto & Julian Parkhill, 2023. "Mutational spectra are associated with bacterial niche," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Fabian König & Sarah L. Svensson & Cynthia M. Sharma, 2024. "Interplay of two small RNAs fine-tunes hierarchical flagella gene expression in Campylobacter jejuni," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    4. Martina O. Chukwu & Akebe Luther King Abia & Eunice Ubomba-Jaswa & Lawrence Obi & John Barr Dewar, 2019. "Characterization and Phylogenetic Analysis of Campylobacter Species Isolated from Paediatric Stool and Water Samples in the Northwest Province, South Africa," IJERPH, MDPI, vol. 16(12), pages 1-22, June.

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