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The language of covalent histone modifications

Author

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  • Brian D. Strahl

    (University of Virginia Health Science Center)

  • C. David Allis

    (University of Virginia Health Science Center)

Abstract

Histone proteins and the nucleosomes they form with DNA are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often occur on tail domains of these proteins has been well documented. Although the function of these highly conserved modifications has remained elusive, converging biochemical and genetic evidence suggests functions in several chromatin-based processes. We propose that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.

Suggested Citation

  • Brian D. Strahl & C. David Allis, 2000. "The language of covalent histone modifications," Nature, Nature, vol. 403(6765), pages 41-45, January.
    • Handle: RePEc:nat:nature:v:403:y:2000:i:6765:d:10.1038_47412
    DOI: 10.1038/47412
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    Cited by:

    1. Sherrie Lessans & Susan G. Dorsey, 2013. "The Role for Epigenetic Modifications in Pain and Analgesia Response," Nursing Research and Practice, Hindawi, vol. 2013, pages 1-6, October.
    2. I. Barnetová & K. Okada, 2010. "Genome reprogramming during the first cell cycle in in vitro produced porcine embryos," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 55(2), pages 49-57.
    3. Tianyi Gao & Bangshun He & Yuqin Pan & Rui Li & Yeqiong Xu & Liping Chen & Zhenling Nie & Ling Gu & Shukui Wang, 2013. "The Association of Retinoic Acid Receptor Beta2(RARβ2) Methylation Status and Prostate Cancer Risk: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-7, May.
    4. Georgios Lagiotis & Panagiotis Madesis & Evangelia Stavridou, 2023. "Echoes of a Stressful Past: Abiotic Stress Memory in Crop Plants towards Enhanced Adaptation," Agriculture, MDPI, vol. 13(11), pages 1-30, November.
    5. Saira Amir & Syed Tahir Abbas Shah & Charalampos Mamoulakis & Anca Oana Docea & Olga-Ioanna Kalantzi & Athanasios Zachariou & Daniela Calina & Felix Carvalho & Nikolaos Sofikitis & Antonios Makrigiann, 2021. "Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review," IJERPH, MDPI, vol. 18(4), pages 1-20, February.
    6. Shijia Zhu & Guohua Wang & Bo Liu & Yadong Wang, 2013. "Modeling Exon Expression Using Histone Modifications," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-15, June.

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