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Toll gates for pathogen selection

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  • Richard J. Ulevitch

    (The Scripps Research Institute)

Abstract

Mammals and flies both stave off pathogens using the innate immune response. In the fruit fly this involves cell-surface receptors belonging to the Toll family, which mediate separate anti-bacterial and anti-fungal responses in the same type of cell. Studies of two mammalian Toll-like receptors, TLR2 and TLR4, indicate that this system is also used in the innate immune responses of higher animals.

Suggested Citation

  • Richard J. Ulevitch, 1999. "Toll gates for pathogen selection," Nature, Nature, vol. 401(6755), pages 755-756, October.
    • Handle: RePEc:nat:nature:v:401:y:1999:i:6755:d:10.1038_44490
    DOI: 10.1038/44490
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    Cited by:

    1. Bangyuan Wu & Hengmin Cui & Xi Peng & Jing Fang & Zhicai Zuo & Junliang Deng & Jianying Huang, 2014. "Analysis of the Toll-Like Receptor 2-2 (TLR2-2) and TLR4 mRNA Expression in the Intestinal Mucosal Immunity of Broilers Fed on Diets Supplemented with Nickel Chloride," IJERPH, MDPI, vol. 11(1), pages 1-14, January.

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