IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v401y1999i6750d10.1038_45829.html
   My bibliography  Save this article

A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion

Author

Listed:
  • Yixin Fu

    (Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine)

  • Jorge E. Galán

    (Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine)

Abstract

An essential feature of the bacterial pathogen Salmonella spp. is its ability to enter cells that are normally non-phagocytic, such as those of the intestinal epithelium1. The bacterium achieves entry by delivering effector proteins into the host-cell cytosol by means of a specialized protein-secretion system (termed type III), which causes reorganization of the cell's actin cytoskeleton and ruffling of its membrane2,3,4. One of the bacterial effectors that stimulates these cellular responses is SopE, which acts as a guanyl-nucleotide-exchange factor on Rho GTPase proteins such as Cdc42 and Rac (ref. 5). As the actin-cytoskeleton reorganization induced by Salmonella is reversible and short-lived, infected cells regain their normal architecture after bacterial internalization6,7. We show here that the S. Typhimurium effector protein SptP, which is delivered to the host-cell cytosol by the type-III secretion system, is directly responsible for the reversal of the actin cytoskeletal changes induced by the bacterium. SptP exerts this function by acting as a GTPase-activating protein (GAP) for Rac-1 and Cdc42.

Suggested Citation

  • Yixin Fu & Jorge E. Galán, 1999. "A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion," Nature, Nature, vol. 401(6750), pages 293-297, September.
    • Handle: RePEc:nat:nature:v:401:y:1999:i:6750:d:10.1038_45829
    DOI: 10.1038/45829
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/45829
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/45829?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Christopher von Beek & Anna Fahlgren & Petra Geiser & Maria Letizia Di Martino & Otto Lindahl & Grisna I. Prensa & Erika Mendez-Enriquez & Jens Eriksson & Jenny Hallgren & Maria Fällman & Gunnar Pejle, 2024. "A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Fabienne Kocher & Violetta Applegate & Jens Reiners & Astrid Port & Dominik Spona & Sebastian Hänsch & Amin Mirzaiebadizi & Mohammad Reza Ahmadian & Sander H. J. Smits & Johannes H. Hegemann & Katja M, 2024. "The Chlamydia pneumoniae effector SemD exploits its host’s endocytic machinery by structural and functional mimicry," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:401:y:1999:i:6750:d:10.1038_45829. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.