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Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis

Author

Listed:
  • Eli A. Stahl

    (University of Chicago)

  • Greg Dwyer

    (University of Chicago)

  • Rodney Mauricio

    (University of Chicago)

  • Martin Kreitman

    (University of Chicago
    University of Chicago)

  • Joy Bergelson

    (University of Chicago
    University of Chicago)

Abstract

The co-evolutionary ‘arms race’1 is a widely accepted model for the evolution of host–pathogen interactions. This model predicts that variation for disease resistance will be transient, and that host populations generally will be monomorphic at disease-resistance (R -gene) loci. However, plant populations show considerable polymorphism at R -gene loci involved in pathogen recognition2. Here we have tested the arms-race model in Arabidopsis thaliana by analysing sequences flanking Rpm1, a gene conferring the ability to recognize Pseudomonas pathogens carrying AvrRpm1 orAvrB (ref. 3). We reject the arms-race hypothesis: resistance andsusceptibility alleles at this locus have co-existed for millions of years. To account for the age of alleles and the relative levels ofpolymorphism within allelic classes, we use coalescence theory to model the long-term accumulation of nucleotide polymorphism in the context of the short-term ecological dynamics of disease resistance. This analysis supports a ‘trench warfare’ hypothesis, inwhich advances and retreats of resistance-allele frequency maintain variation for disease resistance as a dynamic polymorphism4,5.

Suggested Citation

  • Eli A. Stahl & Greg Dwyer & Rodney Mauricio & Martin Kreitman & Joy Bergelson, 1999. "Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis," Nature, Nature, vol. 400(6745), pages 667-671, August.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6745:d:10.1038_23260
    DOI: 10.1038/23260
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    Cited by:

    1. Joo Hyun Im & Brian P Lazzaro, 2018. "Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-17, October.
    2. Antun Skanata & Edo Kussell, 2021. "Ecological memory preserves phage resistance mechanisms in bacteria," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Lewis Stevens & Isaac Martínez-Ugalde & Erna King & Martin Wagah & Dominic Absolon & Rowan Bancroft & Pablo Gonzalez de la Rosa & Jessica L. Hall & Manuela Kieninger & Agnieszka Kloch & Sarah Pelan & , 2023. "Ancient diversity in host-parasite interaction genes in a model parasitic nematode," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    4. M’Gonigle, L.K. & Shen, J.J. & Otto, S.P., 2009. "Mutating away from your enemies: The evolution of mutation rate in a host–parasite system," Theoretical Population Biology, Elsevier, vol. 75(4), pages 301-311.

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