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Dendritic spine changes associated with hippocampal long-term synaptic plasticity

Author

Listed:
  • Florian Engert

    (Max-Planck Institute of Neurobiology)

  • Tobias Bonhoeffer

    (Max-Planck Institute of Neurobiology)

Abstract

Long-term enhancement of synaptic efficacy in the hippocampus is an important model for studying the cellular mechanisms of neuronal plasticity, circuit reorganization, and even learning and memory1. Although these long-lasting functional changes are easy to induce, it has been very difficult to demonstrate that they are accompanied or even caused by morphological changes on the subcellular level. Here we combined a local superfusion technique2,3 with two-photon imaging4, which allowed us to scrutinize specific regions of the postsynaptic dendrite where we knew that the synaptic changes had to occur. We show that after induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrite or in slices where long-term potentiation was blocked, no significant spine growth occurred.

Suggested Citation

  • Florian Engert & Tobias Bonhoeffer, 1999. "Dendritic spine changes associated with hippocampal long-term synaptic plasticity," Nature, Nature, vol. 399(6731), pages 66-70, May.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6731:d:10.1038_19978
    DOI: 10.1038/19978
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    Cited by:

    1. Johannes Holz & Hannah Piosczyk & Nina Landmann & Bernd Feige & Kai Spiegelhalder & Dieter Riemann & Christoph Nissen & Ulrich Voderholzer, 2012. "The Timing of Learning before Night-Time Sleep Differentially Affects Declarative and Procedural Long-Term Memory Consolidation in Adolescents," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-10, July.
    2. Yichen Zhang & Gan He & Lei Ma & Xiaofei Liu & J. J. Johannes Hjorth & Alexander Kozlov & Yutao He & Shenjian Zhang & Jeanette Hellgren Kotaleski & Yonghong Tian & Sten Grillner & Kai Du & Tiejun Huan, 2023. "A GPU-based computational framework that bridges neuron simulation and artificial intelligence," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-29, January.
    4. Joel Bauer & Uwe Lewin & Elizabeth Herbert & Julijana Gjorgjieva & Carl E. Schoonover & Andrew J. P. Fink & Tobias Rose & Tobias Bonhoeffer & Mark Hübener, 2024. "Sensory experience steers representational drift in mouse visual cortex," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Scott R. Burlingham & Nicole F. Wong & Lindsay Peterkin & Lily Lubow & Carolina Dos Santos Passos & Orion Benner & Michael Ghebrial & Thomas P. Cast & Matthew A. Xu-Friedman & Thomas C. Südhof & Soham, 2022. "Induction of synapse formation by de novo neurotransmitter synthesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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