IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v398y1999i6729d10.1038_19539.html
   My bibliography  Save this article

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Author

Listed:
  • Annie Yang

    (Departments of Cell Biology)

  • Ronen Schweitzer

    (Genetics, Harvard Medical School,)

  • Deqin Sun

    (Brigham and Women's Hospital, Harvard Medical School)

  • Mourad Kaghad

    (Sanofi Biorecherche,)

  • Nancy Walker

    (Sanofi Biorecherche,)

  • Roderick T. Bronson

    (Human Nutrition Research Center on Aging, Tufts University School of Veterinary Medicine)

  • Cliff Tabin

    (Genetics, Harvard Medical School,)

  • Arlene Sharpe

    (Immunology Research Division
    Brigham and Women's Hospital, Harvard Medical School)

  • Daniel Caput

    (Sanofi Biorecherche,)

  • Christopher Crum

    (Brigham and Women's Hospital, Harvard Medical School)

  • Frank McKeon

    (Departments of Cell Biology)

Abstract

The p63 gene, a homologue of the tumour-suppressor p53 (1–5), is highly expressed in the basal or progenitor layers of many epithelial tissues1. Here we report that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development. p63 is expressed in the ectodermal surfaces of the limb buds, branchial arches and epidermal appendages, which are all sites of reciprocal signalling that direct morphogenetic patterning of the underlying mesoderm. The limb truncations are due to a failure to maintain the apical ectodermal ridge, a stratified epithelium, essential for limb development. The embryonic epidermis of p63 −/− mice undergoes an unusual process of non-regenerative differentiation, culminating in a striking absence of all squamous epithelia and their derivatives, including mammary, lacrymal and salivary glands. Taken together, our results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis.

Suggested Citation

  • Annie Yang & Ronen Schweitzer & Deqin Sun & Mourad Kaghad & Nancy Walker & Roderick T. Bronson & Cliff Tabin & Arlene Sharpe & Daniel Caput & Christopher Crum & Frank McKeon, 1999. "p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development," Nature, Nature, vol. 398(6729), pages 714-718, April.
    • Handle: RePEc:nat:nature:v:398:y:1999:i:6729:d:10.1038_19539
    DOI: 10.1038/19539
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/19539
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/19539?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Claudia Fierro & Veronica Gatti & Veronica Banca & Sara Domenico & Stefano Scalera & Giacomo Corleone & Maurizio Fanciulli & Francesca Nicola & Alessandro Mauriello & Manuela Montanaro & George A. Cal, 2023. "The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Hisato Nagano & Naoaki Mizuno & Hideyuki Sato & Eiji Mizutani & Ayaka Yanagida & Mayuko Kano & Mariko Kasai & Hiromi Yamamoto & Motoo Watanabe & Fabian Suchy & Hideki Masaki & Hiromitsu Nakauchi, 2024. "Skin graft with dermis and appendages generated in vivo by cell competition," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:398:y:1999:i:6729:d:10.1038_19539. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.