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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Author

Listed:
  • Young-Yun Kong

    (Ontario Cancer Institute, University of Toronto)

  • Hiroki Yoshida

    (Ontario Cancer Institute, University of Toronto)

  • Ildiko Sarosi

    (Amgen Inc., One Amgen Center Drive)

  • Hong-Lin Tan

    (Amgen Inc., One Amgen Center Drive)

  • Emma Timms

    (Amgen Inc., One Amgen Center Drive)

  • Casey Capparelli

    (Amgen Inc., One Amgen Center Drive)

  • Sean Morony

    (Amgen Inc., One Amgen Center Drive)

  • Antonio J. Oliveira-dos-Santos

    (Ontario Cancer Institute, University of Toronto)

  • Gwyneth Van

    (Amgen Inc., One Amgen Center Drive)

  • Annick Itie

    (Ontario Cancer Institute, University of Toronto)

  • Wilson Khoo

    (Ontario Cancer Institute, University of Toronto)

  • Andrew Wakeham

    (Ontario Cancer Institute, University of Toronto)

  • Colin R. Dunstan

    (Amgen Inc., One Amgen Center Drive)

  • David L. Lacey

    (Amgen Inc., One Amgen Center Drive)

  • Tak W. Mak

    (Ontario Cancer Institute, University of Toronto)

  • William J. Boyle

    (Amgen Inc., One Amgen Center Drive)

  • Josef M. Penninger

    (Ontario Cancer Institute, University of Toronto)

Abstract

The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro. Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis. Although dendritic cells appear normal, opgl-deficient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer's patches. Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.

Suggested Citation

  • Young-Yun Kong & Hiroki Yoshida & Ildiko Sarosi & Hong-Lin Tan & Emma Timms & Casey Capparelli & Sean Morony & Antonio J. Oliveira-dos-Santos & Gwyneth Van & Annick Itie & Wilson Khoo & Andrew Wakeham, 1999. "OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis," Nature, Nature, vol. 397(6717), pages 315-323, January.
    • Handle: RePEc:nat:nature:v:397:y:1999:i:6717:d:10.1038_16852
    DOI: 10.1038/16852
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    Cited by:

    1. Tang-Chuan Wang & Che-Chen Lin & Chia-Der Lin & Hsiung-Kwang Chung & Ching-Yuang Wang & Ming-Hsui Tsai & Chia-Hung Kao, 2015. "Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-10, July.
    2. Yongkuk Park & Tadatoshi Sato & Jungwoo Lee, 2023. "Functional and analytical recapitulation of osteoclast biology on demineralized bone paper," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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