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The genome sequence of Rickettsia prowazekii and the origin of mitochondria

Author

Listed:
  • Siv G. E. Andersson

    (University of Uppsala)

  • Alireza Zomorodipour

    (University of Uppsala)

  • Jan O. Andersson

    (University of Uppsala)

  • Thomas Sicheritz-Pontén

    (University of Uppsala)

  • U. Cecilia M. Alsmark

    (University of Uppsala)

  • Raf M. Podowski

    (University of Uppsala)

  • A. Kristina Näslund

    (University of Uppsala)

  • Ann-Sofie Eriksson

    (University of Uppsala)

  • Herbert H. Winkler

    (University of South Alabama)

  • Charles G. Kurland

    (University of Uppsala)

Abstract

We describe here the complete genome sequence (1,111,523 base pairs) of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus. This genome contains 834 protein-coding genes. The functional profiles of these genes show similarities to those of mitochondrial genes: no genes required for anaerobic glycolysis are found in either R. prowazekii or mitochondrial genomes, but a complete set of genes encoding components of the tricarboxylic acid cycle and the respiratory-chain complex is found in R. prowazekii. In effect, ATP production in Rickettsia is the same as that in mitochondria. Many genes involved in the biosynthesis and regulation of biosynthesis of amino acids and nucleosides in free-living bacteria are absent from R. prowazekii and mitochondria. Such genes seem to have been replaced by homologues in the nuclear (host) genome. The R. prowazekii genome contains the highest proportion of non-coding DNA (24%) detected so far in a microbial genome. Such non-coding sequences may be degraded remnants of ‘neutralized’ genes that await elimination from the genome. Phylogenetic analyses indicate that R. prowazekii is more closely related to mitochondria than is any other microbe studied so far.

Suggested Citation

  • Siv G. E. Andersson & Alireza Zomorodipour & Jan O. Andersson & Thomas Sicheritz-Pontén & U. Cecilia M. Alsmark & Raf M. Podowski & A. Kristina Näslund & Ann-Sofie Eriksson & Herbert H. Winkler & Char, 1998. "The genome sequence of Rickettsia prowazekii and the origin of mitochondria," Nature, Nature, vol. 396(6707), pages 133-140, November.
    • Handle: RePEc:nat:nature:v:396:y:1998:i:6707:d:10.1038_24094
    DOI: 10.1038/24094
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    Cited by:

    1. Evelyn Fessler & Luisa Krumwiede & Lucas T. Jae, 2022. "DELE1 tracks perturbed protein import and processing in human mitochondria," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Jian Cui & Jinghua Liu & Yuhua Li & Tieliu Shi, 2011. "Integrative Identification of Arabidopsis Mitochondrial Proteome and Its Function Exploitation through Protein Interaction Network," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-16, January.
    3. Allen G. Sanderlin & Hannah Kurka Margolis & Abigail F. Meyer & Rebecca L. Lamason, 2024. "Cell-selective proteomics reveal novel effectors secreted by an obligate intracellular bacterial pathogen," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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