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Essential role of mouse telomerase in highly proliferative organs

Author

Listed:
  • Han-Woong Lee

    (Albert Einstein College of Medicine
    Ilchun Institute for Molecular Medicine, Seoul National University College of Medicine)

  • Maria A. Blasco

    (Cold Spring Harbor Laboratory
    Universidad Autonoma Madrid, Campus Cantoblanco)

  • Geoffrey J. Gottlieb

    (Quest Diagnostics Incorporated)

  • James W. Horner

    (Albert Einstein College of Medicine)

  • Carol W. Greider

    (Cold Spring Harbor Laboratory
    Johns Hopkins University School of Medicine)

  • Ronald A. DePinho

    (Albert Einstein College of Medicine)

Abstract

We have investigated the role of the enzyme telomerase in highly proliferative organs in successive generations of mice lacking telomerase RNA. Late-generation animals exhibited defective spermatogenesis, with increased programmed cell death (apoptosis) and decreased proliferation in the testis. The proliferative capacity of haematopoietic cells in the bone marrow and spleen was also compromised. These progressively adverse effects coincided with substantial erosion of telomeres (the termini of eukaryotic chromosomes) and fusion and loss of chromosomes. These findings indicate an essential role for telomerase, and hence telomeres, in the maintenance of genomic integrity and in the long-term viability of high-renewal organ systems.

Suggested Citation

  • Han-Woong Lee & Maria A. Blasco & Geoffrey J. Gottlieb & James W. Horner & Carol W. Greider & Ronald A. DePinho, 1998. "Essential role of mouse telomerase in highly proliferative organs," Nature, Nature, vol. 392(6676), pages 569-574, April.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6676:d:10.1038_33345
    DOI: 10.1038/33345
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    Cited by:

    1. Riham Smoom & Catherine Lee May & Vivian Ortiz & Mark Tigue & Hannah M. Kolev & Melissa Rowe & Yitzhak Reizel & Ashleigh Morgan & Nachshon Egyes & Dan Lichtental & Emmanuel Skordalakes & Klaus H. Kaes, 2023. "Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Natthakan Thongon & Feiyang Ma & Andrea Santoni & Matteo Marchesini & Elena Fiorini & Ashley Rose & Vera Adema & Irene Ganan-Gomez & Emma M. Groarke & Fernanda Gutierrez-Rodrigues & Shuaitong Chen & P, 2021. "Hematopoiesis under telomere attrition at the single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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