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Integrin-mediated short-term memory in Drosophila

Author

Listed:
  • Michael S. Grotewiel

    (Baylor College of Medicine)

  • Christine D. O. Beck

    (Baylor College of Medicine)

  • Kwok Hang Wu

    (Columbia University)

  • Xin-Ran Zhu

    (Institut fur Neurale Signalverarbeitung)

  • Ronald L. Davis

    (Baylor College of Medicine)

Abstract

Volado is a new memory mutant of Drosophila. The locus encodes two isoforms of a new α-integrin, a molecule that dynamically mediates cell adhesion and signal transduction. The Volado gene is expressed preferentially in mushroom body cells, which are neurons known to mediate olfactory learning in insects. Volado proteins are concentrated in the mushroom body neuropil, brain areas that contain mushroom body processes in synaptic contact with other neurons. Volado mutants display impaired olfactory memories within 3 min of training, indicating that the integrin is required for short-term memory processes. Conditional expression of a Volado transgene during adulthood rescues the memory impairment. This rescue of memory is reversible, fading over time along with expression of the transgene. Thus the Volado integrin is essential for the physiological processes underlying memory. We propose a model in which integrins act as dynamic regulators of synapse structure or the signalling events underlying short-term memory formation.

Suggested Citation

  • Michael S. Grotewiel & Christine D. O. Beck & Kwok Hang Wu & Xin-Ran Zhu & Ronald L. Davis, 1998. "Integrin-mediated short-term memory in Drosophila," Nature, Nature, vol. 391(6666), pages 455-460, January.
  • Handle: RePEc:nat:nature:v:391:y:1998:i:6666:d:10.1038_35079
    DOI: 10.1038/35079
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    Cited by:

    1. Irmgard U. Haussmann & Yanying Wu & Mohanakarthik P. Nallasivan & Nathan Archer & Zsuzsanna Bodi & Daniel Hebenstreit & Scott Waddell & Rupert Fray & Matthias Soller, 2022. "CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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