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Immunosuppressive effects of apoptotic cells

Author

Listed:
  • Reinhard E. Voll

    (Institute of Clinical Immunology and Rheumatology, University of Erlangen-Nrnberg)

  • Martin Herrmann

    (Institute of Clinical Immunology and Rheumatology, University of Erlangen-Nrnberg)

  • Edith A. Roth

    (Institute of Clinical Immunology and Rheumatology, University of Erlangen-Nrnberg)

  • Christian Stach

    (Institute of Clinical Immunology and Rheumatology, University of Erlangen-Nrnberg)

  • Joachim R. Kalden

    (Institute of Clinical Immunology and Rheumatology, University of Erlangen-Nrnberg)

  • Irute Girkontaite

    (Institute of Experimental Medicine and Connective Tissue Research, University of Erlangen-Nrnberg)

Abstract

Apoptotic cell death is important in the development and homeostasis of multicellular organisms1 and is a highly controlled means of eliminating dangerous, damaged or unnecessary cells without causing an inflammatory response or tissue damage1,2. We now show that the presence of apoptotic cells during monocyte activation increases their secretion of the anti-inflammatory and immunoregulatory cytokine interleukin 10 (IL-10) and decreases secretion of the proinflammatory cytokines tumour necrosis factor-α (TNF-α), IL-1 and IL-12. This may inhibit inflammation and contribute to impaired cell-mediated immunity in conditions associated with increased apoptosis, such as viral infections, pregnancy, cancer and exposure to radiation.

Suggested Citation

  • Reinhard E. Voll & Martin Herrmann & Edith A. Roth & Christian Stach & Joachim R. Kalden & Irute Girkontaite, 1997. "Immunosuppressive effects of apoptotic cells," Nature, Nature, vol. 390(6658), pages 350-351, November.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6658:d:10.1038_37022
    DOI: 10.1038/37022
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    Cited by:

    1. Pascale Leroy & Andrea Tham & Hofer Wong & Rachel Tenney & Chun Chen & Rachel Stiner & John R Balmes & Agnès C Paquet & Mehrdad Arjomandi, 2015. "Inflammatory and Repair Pathways Induced in Human Bronchoalveolar Lavage Cells with Ozone Inhalation," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-28, June.
    2. Swee Heng Milon Pang & Joshua D’Rozario & Senora Mendonca & Tejasvini Bhuvan & Natalie L. Payne & Di Zheng & Assifa Hisana & Georgia Wallis & Adele Barugahare & David Powell & Jai Rautela & Nicholas D, 2021. "Mesenchymal stromal cell apoptosis is required for their therapeutic function," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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