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The same prion strain causes vCJD and BSE

Author

Listed:
  • Andrew F. Hill

    (Prion Disease Group, Neurogenetics Unit, Imperial College School of Medicine at St Marys)

  • Melanie Desbruslais

    (Prion Disease Group, Neurogenetics Unit, Imperial College School of Medicine at St Marys)

  • Susan Joiner

    (Prion Disease Group, Neurogenetics Unit, Imperial College School of Medicine at St Marys)

  • Katie C. L. Sidle

    (Prion Disease Group, Neurogenetics Unit, Imperial College School of Medicine at St Marys)

  • Ian Gowland

    (Prion Disease Group, Neurogenetics Unit, Imperial College School of Medicine at St Marys)

  • John Collinge

    (St Mary's Hospital
    To whom correspondence should be addressed at the Prion Disease Group)

  • Lawrence J. Doey

    (Institute of Psychiatry)

  • Peter Lantos

    (Institute of Psychiatry)

Abstract

Epidemiological and clinicopathological studies, allied with pathological prion protein (PrPSc) analysis, strongly support the hypothesis that the human prion disease new variant Creutzfeldt-Jakob disease (vCJD) is causally related to bovine spongiform encephalopathy (BSE)1,2, but considerable controversy remains. Distinct prion strains are distinguished by their biological properties on transmission to laboratory animals and by physical and chemical differences in PrPSc strains. We now find that the biological and molecular transmission characteristics of vCJD are consistent with it being the human counterpart of BSE.

Suggested Citation

  • Andrew F. Hill & Melanie Desbruslais & Susan Joiner & Katie C. L. Sidle & Ian Gowland & John Collinge & Lawrence J. Doey & Peter Lantos, 1997. "The same prion strain causes vCJD and BSE," Nature, Nature, vol. 389(6650), pages 448-450, October.
    • Handle: RePEc:nat:nature:v:389:y:1997:i:6650:d:10.1038_38925
    DOI: 10.1038/38925
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    Cited by:

    1. A. Gurgul & K. Sieńko & K. Żukowski & K. Pawlina & M. Bugno-Poniewierska, 2014. "Imputation accuracy of bovine spongiform encephalopathy-associated PRNP indel polymorphisms from middle-density SNPs arrays," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 59(5), pages 244-249.
    2. Eric P. M. Grist, 2005. "Transmissible Spongiform Encephalopathy Risk Assessment: The UK experience," Risk Analysis, John Wiley & Sons, vol. 25(3), pages 519-532, June.
    3. Gerald C. Shurson, 2020. "“What a Waste”—Can We Improve Sustainability of Food Animal Production Systems by Recycling Food Waste Streams into Animal Feed in an Era of Health, Climate, and Economic Crises?," Sustainability, MDPI, vol. 12(17), pages 1-34, August.
    4. Didier Calavas & V. Supervie & E. Morignat & D. Costagliola & C. Ducrot, 2007. "Complementary Approach of Data Analysis and Modeling to Estimate the Pattern of the BSE Epidemic: The Example of France," Risk Analysis, John Wiley & Sons, vol. 27(5), pages 1141-1150, October.

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