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Functional rafts in cell membranes

Author

Listed:
  • Kai Simons

    (European Molecular Biology Laboratory, Cell Biology Programme)

  • Elina Ikonen

    (National Public Health Institute)

Abstract

A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.

Suggested Citation

  • Kai Simons & Elina Ikonen, 1997. "Functional rafts in cell membranes," Nature, Nature, vol. 387(6633), pages 569-572, June.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6633:d:10.1038_42408
    DOI: 10.1038/42408
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    Citations

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    Cited by:

    1. Xinchun Zhou & Jinghe Mao & Junmei Ai & Youping Deng & Mary R Roth & Charles Pound & Jeffrey Henegar & Ruth Welti & Steven A Bigler, 2012. "Identification of Plasma Lipid Biomarkers for Prostate Cancer by Lipidomics and Bioinformatics," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-11, November.
    2. Alexander P. Fellows & Ben John & Martin Wolf & Martin Thämer, 2024. "Spiral packing and chiral selectivity in model membranes probed by phase-resolved sum-frequency generation microscopy," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Arun Shivanandan & Jayakrishnan Unnikrishnan & Aleksandra Radenovic, 2015. "Accounting for Limited Detection Efficiency and Localization Precision in Cluster Analysis in Single Molecule Localization Microscopy," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-15, March.
    4. Matthias Pöhnl & Marius F. W. Trollmann & Rainer A. Böckmann, 2023. "Nonuniversal impact of cholesterol on membranes mobility, curvature sensing and elasticity," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    5. Haruka Kemmoku & Kanoko Takahashi & Kojiro Mukai & Toshiki Mori & Koichiro M. Hirosawa & Fumika Kiku & Yasunori Uchida & Yoshihiko Kuchitsu & Yu Nishioka & Masaaki Sawa & Takuma Kishimoto & Kazuma Tan, 2024. "Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Danchin, Antoine, 1999. "From function to sequence, an integrated view of the genome texts," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 273(1), pages 92-98.
    7. Daniel P. Arnold & Yaxin Xu & Sho C. Takatori, 2023. "Antibody binding reports spatial heterogeneities in cell membrane organization," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    8. Marta Ukleja & Lara Kricks & Gabriel Torrens & Ilaria Peschiera & Ines Rodrigues-Lopes & Marcin Krupka & Julia García-Fernández & Roberto Melero & Rosa Campo & Ana Eulalio & André Mateus & María López, 2024. "Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    9. Talia Zeppelin & Lucy Kate Ladefoged & Steffen Sinning & Xavier Periole & Birgit Schiøtt, 2018. "A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition," PLOS Computational Biology, Public Library of Science, vol. 14(1), pages 1-24, January.
    10. Lucas J. Handlin & Natalie L. Macchi & Nicolas L. A. Dumaire & Lyuba Salih & Erin N. Lessie & Kyle S. McCommis & Aubin Moutal & Gucan Dai, 2024. "Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    11. D’Emiliano, D. & Casieri, C. & Paci, M. & De Luca, F., 2007. "Detection of ganglioside clustering in DOPC bilayers by 1H-NMR spectroscopy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 374(1), pages 293-303.

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