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Nucleocytoplasmic transport: signals, mechanisms and regulation

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  • Erich A. Nigg

    (Sciences II, University of Geneva)

Abstract

In eukaryotic organisms, DNA replication and RNA biogenesis occur in the cell nucleus, whereas protein synthesis occurs in the cytoplasm. Integration of these activities depends on selective transport of proteins and ribonucleoprotein particles between the two compartments. Transport across the nuclear envelope occurs through large multiprotein structures, termed nuclear pore complexes. It is signal-mediated and requires both energy and soluble factors, including shuttling carriers. Here I summarize current understanding of nucleocytoplasmic transport and illustrate the importance of regulated transport for signal transduction.

Suggested Citation

  • Erich A. Nigg, 1997. "Nucleocytoplasmic transport: signals, mechanisms and regulation," Nature, Nature, vol. 386(6627), pages 779-787, April.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6627:d:10.1038_386779a0
    DOI: 10.1038/386779a0
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    Cited by:

    1. K. A. Gajewska & H. Lescesen & M. Ramialison & K. M. Wagstaff & D. A. Jans, 2021. "Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Jeffrey J. Ishizuka & Delaney A. Soble & Tiffany Y. Chang & Enrique Peacock-López, 2022. "On the Regulated Nuclear Transport of Incompletely Spliced mRNAs by HIV-Rev Protein: A Minimal Dynamic Model," Mathematics, MDPI, vol. 10(21), pages 1-20, October.

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