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On the Regulated Nuclear Transport of Incompletely Spliced mRNAs by HIV-Rev Protein: A Minimal Dynamic Model

Author

Listed:
  • Jeffrey J. Ishizuka

    (Department of Chemistry, Williams College, Williamstown, MA 01267, USA
    These authors contributed equally to this work.)

  • Delaney A. Soble

    (Department of Chemistry, Williams College, Williamstown, MA 01267, USA
    These authors contributed equally to this work.)

  • Tiffany Y. Chang

    (Department of Chemistry, Williams College, Williamstown, MA 01267, USA
    These authors contributed equally to this work.)

  • Enrique Peacock-López

    (Department of Chemistry, Williams College, Williamstown, MA 01267, USA
    These authors contributed equally to this work.)

Abstract

A kinetic model for the HIV-1 Rev protein is developed by drawing upon mechanistic information from the literature to formulate a set of differential equations modeling the behavior of Rev and its various associated factors over time. A set of results demonstrates the possibility of oscillations in the concentration of these factors. Finally, the results are analyzed, and future directions are discussed.

Suggested Citation

  • Jeffrey J. Ishizuka & Delaney A. Soble & Tiffany Y. Chang & Enrique Peacock-López, 2022. "On the Regulated Nuclear Transport of Incompletely Spliced mRNAs by HIV-Rev Protein: A Minimal Dynamic Model," Mathematics, MDPI, vol. 10(21), pages 1-20, October.
    • Handle: RePEc:gam:jmathe:v:10:y:2022:i:21:p:3922-:d:950333
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    References listed on IDEAS

    as
    1. Erich A. Nigg, 1997. "Nucleocytoplasmic transport: signals, mechanisms and regulation," Nature, Nature, vol. 386(6627), pages 779-787, April.
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