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Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

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Listed:
  • Zhicheng Zeng

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Yuling Li

    (Southern Medical University
    Dongguan People’s hospital)

  • Yangjian Pan

    (The Third Affiliated Hospital of Southern Medical University)

  • Xiaoliang Lan

    (Southern Medical University)

  • Fuyao Song

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Jingbo Sun

    (The Third Affiliated Hospital of Southern Medical University)

  • Kun Zhou

    (The Third Affiliated Hospital of Southern Medical University)

  • Xiaolong Liu

    (The Third Affiliated Hospital of Southern Medical University)

  • Xiaoli Ren

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Feifei Wang

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Jinlong Hu

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Xiaohui Zhu

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Wei Yang

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Wenting Liao

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Guoxin Li

    (Southern Medical University)

  • Yanqing Ding

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

  • Li Liang

    (Nanfang Hospital, Southern Medical University
    Southern Medical University
    Guangdong Province Key Laboratory of Molecular Tumor Pathology)

Abstract

Cancer-derived exosomes are considered a major driver of cancer-induced pre-metastatic niche formation at foreign sites, but the mechanisms remain unclear. Here, we show that miR-25-3p, a metastasis-promoting miRNA of colorectal cancer (CRC), can be transferred from CRC cells to endothelial cells via exosomes. Exosomal miR-25-3p regulates the expression of VEGFR2, ZO-1, occludin and Claudin5 in endothelial cells by targeting KLF2 and KLF4, consequently promotes vascular permeability and angiogenesis. In addition, exosomal miR-25-3p from CRC cells dramatically induces vascular leakiness and enhances CRC metastasis in liver and lung of mice. Moreover, the expression level of miR-25-3p from circulating exosomes is significantly higher in CRC patients with metastasis than those without metastasis. Our work suggests that exosomal miR-25-3p is involved in pre-metastatic niche formation and may be used as a blood-based biomarker for CRC metastasis.

Suggested Citation

  • Zhicheng Zeng & Yuling Li & Yangjian Pan & Xiaoliang Lan & Fuyao Song & Jingbo Sun & Kun Zhou & Xiaolong Liu & Xiaoli Ren & Feifei Wang & Jinlong Hu & Xiaohui Zhu & Wei Yang & Wenting Liao & Guoxin Li, 2018. "Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07810-w
    DOI: 10.1038/s41467-018-07810-w
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    Cited by:

    1. Dan Zhao & Kerui Wu & Sambad Sharma & Fei Xing & Shih-Ying Wu & Abhishek Tyagi & Ravindra Deshpande & Ravi Singh & Martin Wabitsch & Yin-Yuan Mo & Kounosuke Watabe, 2022. "Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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