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The disease resistance protein SNC1 represses the biogenesis of microRNAs and phased siRNAs

Author

Listed:
  • Qiang Cai

    (Shenzhen University
    Shenzhen University)

  • Chao Liang

    (Shenzhen University
    Shenzhen University)

  • Suikang Wang

    (Shenzhen University
    University of California)

  • Yingnan Hou

    (University of California)

  • Lei Gao

    (Shenzhen University)

  • Li Liu

    (University of California)

  • Wenrong He

    (University of California)

  • Wenbo Ma

    (University of California)

  • Beixin Mo

    (Shenzhen University)

  • Xuemei Chen

    (University of California)

Abstract

Plants evolved an array of disease resistance genes (R genes) to fight pathogens. In the absence of pathogen infection, NBS-LRR genes, which comprise a major subfamily of R genes, are suppressed by a small RNA cascade involving microRNAs (miRNAs) that trigger the biogenesis of phased siRNAs (phasiRNAs) from R gene transcripts. However, whether or how R genes influence small RNA biogenesis is unknown. In this study, we isolate a mutant with global defects in the biogenesis of miRNAs and phasiRNAs in Arabidopsis thaliana and trace the defects to the over accumulation and nuclear localization of an R protein SNC1. We show that nuclear SNC1 represses the transcription of miRNA and phasiRNA loci, probably through the transcriptional corepressor TPR1. Intriguingly, nuclear SNC1 reduces the accumulation of phasiRNAs from three source R genes and concomitantly, the expression of a majority of the ~170R genes is up-regulated. Taken together, this study suggests an R gene-miRNA-phasiRNA regulatory module that amplifies plant immune responses.

Suggested Citation

  • Qiang Cai & Chao Liang & Suikang Wang & Yingnan Hou & Lei Gao & Li Liu & Wenrong He & Wenbo Ma & Beixin Mo & Xuemei Chen, 2018. "The disease resistance protein SNC1 represses the biogenesis of microRNAs and phased siRNAs," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07516-z
    DOI: 10.1038/s41467-018-07516-z
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    Cited by:

    1. Chao Liang & Qiang Cai & Fei Wang & Shaofang Li & Chenjiang You & Chi Xu & Lei Gao & Dechang Cao & Ting Lan & Bailong Zhang & Beixin Mo & Xuemei Chen, 2022. "Arabidopsis RBV is a conserved WD40 repeat protein that promotes microRNA biogenesis and ARGONAUTE1 loading," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Bangjun Zhou & Huihui Yu & Yong Xue & Mu Li & Chi Zhang & Bin Yu, 2024. "The spliceosome-associated protein CWC15 promotes miRNA biogenesis in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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