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Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection

Author

Listed:
  • Sasirekha Ramani

    (Baylor College of Medicine)

  • Christopher J. Stewart

    (Baylor College of Medicine
    Newcastle University)

  • Daniel R. Laucirica

    (Baylor College of Medicine)

  • Nadim J. Ajami

    (Baylor College of Medicine)

  • Bianca Robertson

    (University of California, San Diego)

  • Chloe A. Autran

    (University of California, San Diego)

  • Dhairyasheel Shinge

    (Christian Medical College)

  • Sandya Rani

    (Christian Medical College)

  • Sasirekha Anandan

    (Christian Medical College)

  • Liya Hu

    (Baylor College of Medicine)

  • Josephine C. Ferreon

    (Baylor College of Medicine)

  • Kurien A. Kuruvilla

    (Christian Medical College)

  • Joseph F. Petrosino

    (Baylor College of Medicine
    Baylor College of Medicine)

  • B. V. Venkataram Prasad

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Lars Bode

    (University of California, San Diego)

  • Gagandeep Kang

    (Christian Medical College
    Translational Health Science and Technology Institute)

  • Mary K. Estes

    (Baylor College of Medicine
    Baylor College of Medicine)

Abstract

Neonatal rotavirus infections are predominantly asymptomatic. While an association with gastrointestinal symptoms has been described in some settings, factors influencing differences in clinical presentation are not well understood. Using multidisciplinary approaches, we show that a complex interplay between human milk oligosaccharides (HMOs), milk microbiome, and infant gut microbiome impacts neonatal rotavirus infections. Validating in vitro studies where HMOs are not decoy receptors for neonatal strain G10P[11], population studies show significantly higher levels of Lacto-N-tetraose (LNT), 2’-fucosyllactose (2’FL), and 6’-siallylactose (6’SL) in milk from mothers of rotavirus-positive neonates with gastrointestinal symptoms. Further, these HMOs correlate with abundance of Enterobacter/Klebsiella in maternal milk and infant stool. Specific HMOs also improve the infectivity of a neonatal strain-derived rotavirus vaccine. This study provides molecular and translational insight into host factors influencing neonatal rotavirus infections and identifies maternal components that could promote the performance of live, attenuated rotavirus vaccines.

Suggested Citation

  • Sasirekha Ramani & Christopher J. Stewart & Daniel R. Laucirica & Nadim J. Ajami & Bianca Robertson & Chloe A. Autran & Dhairyasheel Shinge & Sandya Rani & Sasirekha Anandan & Liya Hu & Josephine C. F, 2018. "Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07476-4
    DOI: 10.1038/s41467-018-07476-4
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    Cited by:

    1. Kelsey E. Johnson & Nelmary Hernandez-Alvarado & Mark Blackstad & Timothy Heisel & Mattea Allert & David A. Fields & Elvira Isganaitis & Katherine M. Jacobs & Dan Knights & Eric F. Lock & Michael C. R, 2024. "Human cytomegalovirus in breast milk is associated with milk composition and the infant gut microbiome and growth," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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