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Non-obstructive intracellular nanolasers

Author

Listed:
  • Alasdair H. Fikouras

    (SUPA, School of Physics and Astronomy, University of St Andrews)

  • Marcel Schubert

    (SUPA, School of Physics and Astronomy, University of St Andrews)

  • Markus Karl

    (SUPA, School of Physics and Astronomy, University of St Andrews)

  • Jothi D. Kumar

    (SUPA, School of Physics and Astronomy, University of St Andrews)

  • Simon J. Powis

    (School of Medicine, University of St Andrews)

  • Andrea Di Falco

    (SUPA, School of Physics and Astronomy, University of St Andrews)

  • Malte C. Gather

    (SUPA, School of Physics and Astronomy, University of St Andrews)

Abstract

Molecular dyes, plasmonic nanoparticles and colloidal quantum dots are widely used in biomedical optics. Their operation is usually governed by spontaneous processes, which results in broad spectral features and limited signal-to-noise ratio, thus restricting opportunities for spectral multiplexing and sensing. Lasers provide the ultimate spectral definition and background suppression, and their integration with cells has recently been demonstrated. However, laser size and threshold remain problematic. Here, we report on the design, high-throughput fabrication and intracellular integration of semiconductor nanodisk lasers. By exploiting the large optical gain and high refractive index of GaInP/AlGaInP quantum wells, we obtain lasers with volumes 1000-fold smaller than the eukaryotic nucleus (Vlaser

Suggested Citation

  • Alasdair H. Fikouras & Marcel Schubert & Markus Karl & Jothi D. Kumar & Simon J. Powis & Andrea Di Falco & Malte C. Gather, 2018. "Non-obstructive intracellular nanolasers," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07248-0
    DOI: 10.1038/s41467-018-07248-0
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    Cited by:

    1. Guocheng Fang & Zhen Qiao & Luqi Huang & Hui Zhu & Jun Xie & Tian Zhou & Zhongshu Xiong & I-Hsin Su & Dayong Jin & Yu-Cheng Chen, 2024. "Single-cell laser emitting cytometry for label-free nucleolus fingerprinting," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Yaping Wang & Marion C. Lang & Jinsong Lu & Mingqian Suo & Mengcong Du & Yubin Hou & Xiu-Hong Wang & Pu Wang, 2022. "Demonstration of intracellular real-time molecular quantification via FRET-enhanced optical microcavity," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Aljaž Kavčič & Maja Garvas & Matevž Marinčič & Katrin Unger & Anna Maria Coclite & Boris Majaron & Matjaž Humar, 2022. "Deep tissue localization and sensing using optical microcavity probes," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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