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Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus

Author

Listed:
  • Claudia Espinoza

    (IST Austria (Institute of Science and Technology Austria))

  • Segundo Jose Guzman

    (Institute for Molecular Biotechnology (IMBA))

  • Xiaomin Zhang

    (IST Austria (Institute of Science and Technology Austria))

  • Peter Jonas

    (IST Austria (Institute of Science and Technology Austria))

Abstract

Parvalbumin-positive (PV+) GABAergic interneurons in hippocampal microcircuits are thought to play a key role in several higher network functions, such as feedforward and feedback inhibition, network oscillations, and pattern separation. Fast lateral inhibition mediated by GABAergic interneurons may implement a winner-takes-all mechanism in the hippocampal input layer. However, it is not clear whether the functional connectivity rules of granule cells (GCs) and interneurons in the dentate gyrus are consistent with such a mechanism. Using simultaneous patch-clamp recordings from up to seven GCs and up to four PV+ interneurons in the dentate gyrus, we find that connectivity is structured in space, synapse-specific, and enriched in specific disynaptic motifs. In contrast to the neocortex, lateral inhibition in the dentate gyrus (in which a GC inhibits neighboring GCs via a PV+ interneuron) is ~ 10-times more abundant than recurrent inhibition (in which a GC inhibits itself). Thus, unique connectivity rules may enable the dentate gyrus to perform specific higher-order computations.

Suggested Citation

  • Claudia Espinoza & Segundo Jose Guzman & Xiaomin Zhang & Peter Jonas, 2018. "Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06899-3
    DOI: 10.1038/s41467-018-06899-3
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    Cited by:

    1. Douglas Feitosa Tomé & Sadra Sadeh & Claudia Clopath, 2022. "Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Daniel Müller-Komorowska & Baris Kuru & Heinz Beck & Oliver Braganza, 2023. "Phase information is conserved in sparse, synchronous population-rate-codes via phase-to-rate recoding," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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