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Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system

Author

Listed:
  • Charles Petitpré

    (Karolinska Institutet, Biomedicum)

  • Haohao Wu

    (Karolinska Institutet, Biomedicum)

  • Anil Sharma

    (Karolinska Institutet, Biomedicum)

  • Anna Tokarska

    (Karolinska Institutet, Biomedicum)

  • Paula Fontanet

    (Karolinska Institutet, Biomedicum)

  • Yiqiao Wang

    (Karolinska Institutet, Biomedicum)

  • Françoise Helmbacher

    (Aix-Marseille Université, CNRS UMR7288, Institut de Biologie du Développement de Marseille (IBDM))

  • Kevin Yackle

    (University of California–San Francisco)

  • Gilad Silberberg

    (Karolinska Institutet, Biomedicum)

  • Saida Hadjab

    (Karolinska Institutet, Biomedicum)

  • François Lallemend

    (Karolinska Institutet, Biomedicum)

Abstract

Spiral ganglion (SG) neurons of the cochlea convey all auditory inputs to the brain, yet the cellular and molecular complexity necessary to decode the various acoustic features in the SG has remained unresolved. Using single-cell RNA sequencing, we identify four types of SG neurons, including three novel subclasses of type I neurons and the type II neurons, and provide a comprehensive genetic framework that define their potential synaptic communication patterns. The connectivity patterns of the three subclasses of type I neurons with inner hair cells and their electrophysiological profiles suggest that they represent the intensity-coding properties of auditory afferents. Moreover, neuron type specification is already established at birth, indicating a neuronal diversification process independent of neuronal activity. Thus, this work provides a transcriptional catalog of neuron types in the cochlea, which serves as a valuable resource for dissecting cell-type-specific functions of dedicated afferents in auditory perception and in hearing disorders.

Suggested Citation

  • Charles Petitpré & Haohao Wu & Anil Sharma & Anna Tokarska & Paula Fontanet & Yiqiao Wang & Françoise Helmbacher & Kevin Yackle & Gilad Silberberg & Saida Hadjab & François Lallemend, 2018. "Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06033-3
    DOI: 10.1038/s41467-018-06033-3
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    Cited by:

    1. Charles Petitpré & Louis Faure & Phoebe Uhl & Paula Fontanet & Iva Filova & Gabriela Pavlinkova & Igor Adameyko & Saida Hadjab & Francois Lallemend, 2022. "Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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