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Evaluating intrinsic and non-intrinsic cancer risk factors

Author

Listed:
  • Song Wu

    (Stony Brook University
    Health Sciences Centre)

  • Wei Zhu

    (Stony Brook University
    Health Sciences Centre)

  • Patricia Thompson

    (Health Sciences Centre
    Health Sciences Centre)

  • Yusuf A Hannun

    (Health Sciences Centre
    Health Sciences Centre)

Abstract

Discriminating the contribution of unmodifiable random intrinsic DNA replication errors (‘bad luck’) to cancer development from those of other factors is critical for understanding cancer in humans and for directing public resources aimed at reducing the burden of cancer. Here, we review and highlight the evidence that demonstrates cancer causation is multifactorial, and provide several important examples where modification of risk factors has achieved cancer prevention. Furthermore, we stress the need and opportunities to advance understanding of cancer aetiology through integration of interaction effects between risk factors when estimating the contribution of individual and joint factors to cancer burden in a population. We posit that non-intrinsic factors drive most cancer risk, and stress the need for cancer prevention.

Suggested Citation

  • Song Wu & Wei Zhu & Patricia Thompson & Yusuf A Hannun, 2018. "Evaluating intrinsic and non-intrinsic cancer risk factors," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05467-z
    DOI: 10.1038/s41467-018-05467-z
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    Cited by:

    1. Anna Halama & Shaza Zaghlool & Gaurav Thareja & Sara Kader & Wadha Al Muftah & Marjonneke Mook-Kanamori & Hina Sarwath & Yasmin Ali Mohamoud & Nisha Stephan & Sabine Ameling & Maja Pucic Baković & Jan, 2024. "A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Daniela Cesana & Maria Pia Cicalese & Andrea Calabria & Pietro Merli & Roberta Caruso & Monica Volpin & Laura Rudilosso & Maddalena Migliavacca & Federica Barzaghi & Claudia Fossati & Francesco Gazzo , 2024. "A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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