IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05384-1.html
   My bibliography  Save this article

Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

Author

Listed:
  • Juan Guan

    (Fudan University
    Ministry of Education)

  • Qing Shen

    (Shanghai Jiao Tong University)

  • Zui Zhang

    (Fudan University
    Ministry of Education)

  • Zhuxuan Jiang

    (Fudan University)

  • Yang Yang

    (Fudan University)

  • Meiqing Lou

    (Shanghai Jiaotong University)

  • Jun Qian

    (Ministry of Education)

  • Weiyue Lu

    (Ministry of Education)

  • Changyou Zhan

    (Fudan University
    Ministry of Education)

Abstract

Targeting ligands are anticipated to facilitate the precise delivery of therapeutic agents to diseased tissues; however, they may also severely affect the interaction of nanocarriers with plasma proteins. Here, we study the immunocompatibility of brain-targeted liposomes, which inversely correlates with absorbed natural IgM. Modification of long, stable positively charged peptide ligands on liposomes is inclined to absorb natural IgM, leading to rapid clearance and enhanced immunogenicity. Small peptidomimetic D8 developed by computer-aided peptide design exhibits improved immunocompatibility by attenuating natural IgM absorption. The present study highlights the effects of peptide ligands on the formed protein corona and in vivo fate of liposomes. Stable positively charged peptide ligands play double-edged roles in targeted delivery, preserving in vivo bioactivities for binding receptors and long-term unfavorable interactions with the innate immune system. The development of D8 provides insights into how to rationally design immunocompatible drug delivery systems by modulating the protein corona composition.

Suggested Citation

  • Juan Guan & Qing Shen & Zui Zhang & Zhuxuan Jiang & Yang Yang & Meiqing Lou & Jun Qian & Weiyue Lu & Changyou Zhan, 2018. "Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05384-1
    DOI: 10.1038/s41467-018-05384-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05384-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05384-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lin Li & Mengxing Zhang & Jing Li & Tiantian Liu & Qixue Bao & Xi Li & Jiaying Long & Leyao Fu & Zhirong Zhang & Shiqi Huang & Zhenmi Liu & Ling Zhang, 2023. "Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05384-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.