IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05325-y.html
   My bibliography  Save this article

Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

Author

Listed:
  • Axel Weber

    (Justus-Liebig-Universität)

  • Sigrid C. Schwarz

    (Technische Universität München
    German Center for Neurodegenerative Diseases (DZNE))

  • Jörg Tost

    (CEA—Institut de Biologie Francois Jacob)

  • Dietrich Trümbach

    (Helmholtz Center München)

  • Pia Winter

    (Justus-Liebig-Universität)

  • Florence Busato

    (CEA—Institut de Biologie Francois Jacob)

  • Pawel Tacik

    (Mayo Clinic
    University of Bonn Medical Center)

  • Anita C. Windhorst

    (Justus-Liebig-Universität)

  • Maud Fagny

    (CEA—Institut de Biologie Francois Jacob)

  • Thomas Arzberger

    (German Center for Neurodegenerative Diseases (DZNE)
    Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität)

  • Catriona McLean

    (Victorian Brain Bank)

  • John C. Swieten

    (Erasmus Medical Centre)

  • Johannes Schwarz

    (Technische Universität München)

  • Daniela Vogt Weisenhorn

    (German Center for Neurodegenerative Diseases (DZNE)
    Helmholtz Center München
    Technische Universität München-Weihenstephan)

  • Wolfgang Wurst

    (German Center for Neurodegenerative Diseases (DZNE)
    Helmholtz Center München
    Technische Universität München-Weihenstephan
    Munich Cluster for Systems Neurology (SyNergy))

  • Till Adhikary

    (Philipps University)

  • Dennis W. Dickson

    (Mayo Clinic)

  • Günter U. Höglinger

    (Technische Universität München
    German Center for Neurodegenerative Diseases (DZNE)
    Munich Cluster for Systems Neurology (SyNergy))

  • Ulrich Müller

    (Justus-Liebig-Universität)

Abstract

Genetic, epigenetic, and environmental factors contribute to the multifactorial disorder progressive supranuclear palsy (PSP). Here, we study epigenetic changes by genome-wide analysis of DNA from postmortem tissue of forebrains of patients and controls and detect significant (P

Suggested Citation

  • Axel Weber & Sigrid C. Schwarz & Jörg Tost & Dietrich Trümbach & Pia Winter & Florence Busato & Pawel Tacik & Anita C. Windhorst & Maud Fagny & Thomas Arzberger & Catriona McLean & John C. Swieten & J, 2018. "Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05325-y
    DOI: 10.1038/s41467-018-05325-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05325-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05325-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Qing Bai & Enhua Shao & Denglei Ma & Binxuan Jiao & Seth D. Scheetz & Karen A. Hartnett-Scott & Vladimir A. Ilin & Elias Aizenman & Julia Kofler & Edward A. Burton, 2024. "A human Tau expressing zebrafish model of progressive supranuclear palsy identifies Brd4 as a regulator of microglial synaptic elimination," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05325-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.