IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05237-x.html
   My bibliography  Save this article

Non plasmonic semiconductor quantum SERS probe as a pathway for in vitro cancer detection

Author

Listed:
  • Rupa Haldavnekar

    (Ryerson University
    Ryerson University)

  • Krishnan Venkatakrishnan

    (Ryerson University
    Ryerson University
    St. Michael’s Hospital)

  • Bo Tan

    (Ryerson University)

Abstract

Surface-enhanced Raman scattering (SERS)-based cancer diagnostics is an important analytical tool in early detection of cancer. Current work in SERS focuses on plasmonic nanomaterials that suffer from coagulation, selectivity, and adverse biocompatibility when used in vitro, limiting this research to stand-alone biomolecule sensing. Here we introduce a label-free, biocompatible, ZnO-based, 3D semiconductor quantum probe as a pathway for in vitro diagnosis of cancer. By reducing size of the probes to quantum scale, we observed a unique phenomenon of exponential increase in the SERS enhancement up to ~106 at nanomolar concentration. The quantum probes are decorated on a nano-dendrite platform functionalized for cell adhesion, proliferation, and label-free application. The quantum probes demonstrate discrimination of cancerous and non-cancerous cells along with biomolecular sensing of DNA, RNA, proteins and lipids in vitro. The limit of detection is up to a single-cell-level detection.

Suggested Citation

  • Rupa Haldavnekar & Krishnan Venkatakrishnan & Bo Tan, 2018. "Non plasmonic semiconductor quantum SERS probe as a pathway for in vitro cancer detection," Nature Communications, Nature, vol. 9(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05237-x
    DOI: 10.1038/s41467-018-05237-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05237-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05237-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Deeptha Ishwar & Rupa Haldavnekar & Krishnan Venkatakrishnan & Bo Tan, 2022. "Minimally invasive detection of cancer using metabolic changes in tumor-associated natural killer cells with Oncoimmune probes," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Chenhao Gao & Keyi Zhong & Xuan Fang & Dan Fang & Hongbin Zhao & Dengkui Wang & Bobo Li & Yingjiao Zhai & Xueying Chu & Jinhua Li & Xiaohua Wang, 2021. "Brief Review of Photocatalysis and Photoresponse Properties of ZnO–Graphene Nanocomposites," Energies, MDPI, vol. 14(19), pages 1-25, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05237-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.