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Ependymal cilia beating induces an actin network to protect centrioles against shear stress

Author

Listed:
  • Alexia Mahuzier

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS))

  • Asm Shihavuddin

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS)
    Technical University of Denmark, Kgs)

  • Clémence Fournier

    (Biochimie Biophysique et Biologie Structurale
    Sorbonne Université)

  • Pauline Lansade

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS))

  • Marion Faucourt

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS))

  • Nikita Menezes

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS))

  • Alice Meunier

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS))

  • Meriem Garfa-Traoré

    (Paris Descartes Sorbonne Paris Cité University)

  • Marie-France Carlier

    (Biochimie Biophysique et Biologie Structurale)

  • Raphael Voituriez

    (Laboratoire de Physique Théorique de la Matière Condensée, CNRS/UPMC
    Laboratoire Jean Perrin, CNRS/UPMC)

  • Auguste Genovesio

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS))

  • Nathalie Spassky

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS))

  • Nathalie Delgehyr

    (Cilia biology and neurogenesis, Institut de biologie de l’Ecole normale supérieure (IBENS))

Abstract

Multiciliated ependymal cells line all brain cavities. The beating of their motile cilia contributes to the flow of cerebrospinal fluid, which is required for brain homoeostasis and functions. Motile cilia, nucleated from centrioles, persist once formed and withstand the forces produced by the external fluid flow and by their own cilia beating. Here, we show that a dense actin network around the centrioles is induced by cilia beating, as shown by the disorganisation of the actin network upon impairment of cilia motility. Moreover, disruption of the actin network, or specifically of the apical actin network, causes motile cilia and their centrioles to detach from the apical surface of ependymal cell. In conclusion, cilia beating controls the apical actin network around centrioles; the mechanical resistance of this actin network contributes, in turn, to centriole stability.

Suggested Citation

  • Alexia Mahuzier & Asm Shihavuddin & Clémence Fournier & Pauline Lansade & Marion Faucourt & Nikita Menezes & Alice Meunier & Meriem Garfa-Traoré & Marie-France Carlier & Raphael Voituriez & Auguste Ge, 2018. "Ependymal cilia beating induces an actin network to protect centrioles against shear stress," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04676-w
    DOI: 10.1038/s41467-018-04676-w
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    Cited by:

    1. Takayuki Yasunaga & Johannes Wiegel & Max D. Bergen & Martin Helmstädter & Daniel Epting & Andrea Paolini & Özgün Çiçek & Gerald Radziwill & Christina Engel & Thomas Brox & Olaf Ronneberger & Peter Wa, 2022. "Microridge-like structures anchor motile cilia," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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