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Progress and challenges towards targeted delivery of cancer therapeutics

Author

Listed:
  • Daniel Rosenblum

    (Cancer Biology Research Center, Tel Aviv University)

  • Nitin Joshi

    (Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
    Harvard-Massachusetts Division of Health Science and Technology)

  • Wei Tao

    (Harvard Medical School)

  • Jeffrey M. Karp

    (Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
    Harvard-Massachusetts Division of Health Science and Technology)

  • Dan Peer

    (Cancer Biology Research Center, Tel Aviv University)

Abstract

Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, only 15 passively targeted nanocarriers (NCs) have been approved for clinical use and none of the actively targeted NCs have advanced past clinical trials. Herein, we review the principles behind targeted delivery approaches to determine potential reasons for their limited clinical translation and success. We propose criteria and considerations that must be taken into account for the development of novel actively targeted NCs. We also highlight the possible directions for the development of successful tumor targeting strategies.

Suggested Citation

  • Daniel Rosenblum & Nitin Joshi & Wei Tao & Jeffrey M. Karp & Dan Peer, 2018. "Progress and challenges towards targeted delivery of cancer therapeutics," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03705-y
    DOI: 10.1038/s41467-018-03705-y
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    Cited by:

    1. Chaoyu Wang & Ruoshi Zhang & Jia He & Lvshan Yu & Xinyan Li & Junxia Zhang & Sai Li & Conggang Zhang & Jonathan C. Kagan & Jeffrey M. Karp & Rui Kuai, 2023. "Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Junbin Gao & Hanfeng Qin & Fei Wang & Lu Liu & Hao Tian & Hong Wang & Shuanghu Wang & Juanfeng Ou & Yicheng Ye & Fei Peng & Yingfeng Tu, 2023. "Hyperthermia-triggered biomimetic bubble nanomachines," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Seong Eun Lee & Seongyeol Park & Shinae Yi & Na Rae Choi & Mi Ae Lim & Jae Won Chang & Ho-Ryun Won & Je Ryong Kim & Hye Mi Ko & Eun-Jae Chung & Young Joo Park & Sun Wook Cho & Hyeong Won Yu & June You, 2024. "Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Qi Cai & Xiaoqing Li & Hejian Xiong & Hanwen Fan & Xiaofei Gao & Vamsidhara Vemireddy & Ryan Margolis & Junjie Li & Xiaoqian Ge & Monica Giannotta & Kenneth Hoyt & Elizabeth Maher & Robert Bachoo & Zh, 2023. "Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Ziyang Cao & Dongdong Li & Liang Zhao & Mengting Liu & Pengyue Ma & Yingli Luo & Xianzhu Yang, 2022. "Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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