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Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer

Author

Listed:
  • Jutaek Nam

    (University of Michigan
    University of Michigan)

  • Sejin Son

    (University of Michigan
    University of Michigan)

  • Lukasz J. Ochyl

    (University of Michigan
    University of Michigan)

  • Rui Kuai

    (University of Michigan
    University of Michigan)

  • Anna Schwendeman

    (University of Michigan
    University of Michigan)

  • James J. Moon

    (University of Michigan
    University of Michigan
    University of Michigan)

Abstract

Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumor immunity against disseminated tumors. Specifically, we have developed polydopamine-coated spiky gold nanoparticles as a new photothermal agent with extensive photothermal stability and efficiency. Strikingly, a single round of PTT combined with a sub-therapeutic dose of doxorubicin can elicit robust anti-tumor immune responses and eliminate local as well as untreated, distant tumors in >85% of animals bearing CT26 colon carcinoma. We also demonstrate their therapeutic efficacy against TC-1 submucosa-lung metastasis, a highly aggressive model for advanced head and neck squamous cell carcinoma (HNSCC). Our study sheds new light on a previously unrecognized, immunological facet of chemo-photothermal therapy and may lead to new therapeutic strategies against advanced cancer.

Suggested Citation

  • Jutaek Nam & Sejin Son & Lukasz J. Ochyl & Rui Kuai & Anna Schwendeman & James J. Moon, 2018. "Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03473-9
    DOI: 10.1038/s41467-018-03473-9
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    Cited by:

    1. Zhaoqing Shi & Miaomiao Luo & Qili Huang & Chendi Ding & Wenyan Wang & Yinglong Wu & Jingjing Luo & Chuchu Lin & Ting Chen & Xiaowei Zeng & Lin Mei & Yanli Zhao & Hongzhong Chen, 2023. "NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Jia He & Chaoyu Wang & Xiao Fang & Junyao Li & Xueying Shen & Junxia Zhang & Cheng Peng & Hongjian Li & Sai Li & Jeffrey M. Karp & Rui Kuai, 2024. "Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Huapan Fang & Zhaopei Guo & Jie Chen & Lin Lin & Yingying Hu & Yanhui Li & Huayu Tian & Xuesi Chen, 2021. "Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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