IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-03315-8.html
   My bibliography  Save this article

Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications

Author

Listed:
  • Lixiong Dai

    (The Hong Kong Polytechnic University)

  • Chloe M. Jones

    (Massachusetts General Hospital and Harvard Medical School)

  • Wesley Ting Kwok Chan

    (The Hong Kong Polytechnic University)

  • Tiffany A. Pham

    (University of Pittsburgh)

  • Xiaoxi Ling

    (University of Pittsburgh)

  • Eric M. Gale

    (Massachusetts General Hospital and Harvard Medical School)

  • Nicholas J. Rotile

    (Massachusetts General Hospital and Harvard Medical School)

  • William Chi-Shing Tai

    (The Hong Kong Polytechnic University)

  • Carolyn J. Anderson

    (University of Pittsburgh
    University of Pittsburgh
    University of Pittsburgh)

  • Peter Caravan

    (Massachusetts General Hospital and Harvard Medical School)

  • Ga-Lai Law

    (The Hong Kong Polytechnic University)

Abstract

Despite established clinical utilisation, there is an increasing need for safer, more inert gadolinium-based contrast agents, and for chelators that react rapidly with radiometals. Here we report the syntheses of a series of chiral DOTA chelators and their corresponding metal complexes and reveal properties that transcend the parent DOTA compound. We incorporated symmetrical chiral substituents around the tetraaza ring, imparting enhanced rigidity to the DOTA cavity, enabling control over the range of stereoisomers of the lanthanide complexes. The Gd chiral DOTA complexes are shown to be orders of magnitude more inert to Gd release than [GdDOTA]−. These compounds also exhibit very-fast water exchange rates in an optimal range for high field imaging. Radiolabeling studies with (Cu-64/Lu-177) also demonstrate faster labelling properties. These chiral DOTA chelators are alternative general platforms for the development of stable, high relaxivity contrast agents, and for radiometal complexes used for imaging and/or therapy.

Suggested Citation

  • Lixiong Dai & Chloe M. Jones & Wesley Ting Kwok Chan & Tiffany A. Pham & Xiaoxi Ling & Eric M. Gale & Nicholas J. Rotile & William Chi-Shing Tai & Carolyn J. Anderson & Peter Caravan & Ga-Lai Law, 2018. "Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03315-8
    DOI: 10.1038/s41467-018-03315-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-03315-8
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-018-03315-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ufuk Kilic & Matthew Hilfiker & Shawn Wimer & Alexander Ruder & Eva Schubert & Mathias Schubert & Christos Argyropoulos, 2024. "Controlling the broadband enhanced light chirality with L-shaped dielectric metamaterials," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Tomáš David & Miroslava Šedinová & Aneta Myšková & Jaroslav Kuneš & Lenka Maletínská & Radek Pohl & Martin Dračínský & Helena Mertlíková-Kaiserová & Karel Čížek & Blanka Klepetářová & Miroslava Liteck, 2024. "Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03315-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.