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An olfactory virtual reality system for mice

Author

Listed:
  • Brad A. Radvansky

    (Northwestern University)

  • Daniel A. Dombeck

    (Northwestern University)

Abstract

All motile organisms use spatially distributed chemical features of their surroundings to guide their behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult to study, largely due to the technical challenges of controlling chemical concentrations in space and time during behavioral experiments. To overcome these challenges, we introduce a system to control and maintain an olfactory virtual landscape. This system uses rapid flow controllers and an online predictive algorithm to deliver precise odorant distributions to head-fixed mice as they explore a virtual environment. We establish an odor-guided virtual navigation behavior that engages hippocampal CA1 “place cells” that exhibit similar properties to those previously reported for real and visual virtual environments, demonstrating that navigation based on different sensory modalities recruits a similar cognitive map. This method opens new possibilities for studying the neural mechanisms of olfactory-driven behaviors, multisensory integration, innate valence, and low-dimensional sensory-spatial processing.

Suggested Citation

  • Brad A. Radvansky & Daniel A. Dombeck, 2018. "An olfactory virtual reality system for mice," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03262-4
    DOI: 10.1038/s41467-018-03262-4
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    Cited by:

    1. Yiming Liu & Chun Ki Yiu & Zhao Zhao & Wooyoung Park & Rui Shi & Xingcan Huang & Yuyang Zeng & Kuan Wang & Tsz Hung Wong & Shengxin Jia & Jingkun Zhou & Zhan Gao & Ling Zhao & Kuanming Yao & Jian Li &, 2023. "Soft, miniaturized, wireless olfactory interface for virtual reality," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Samuel K. H. Sy & Danny C. W. Chan & Roy C. H. Chan & Jing Lyu & Zhongqi Li & Kenneth K. Y. Wong & Chung Hang Jonathan Choi & Vincent C. T. Mok & Hei-Ming Lai & Owen Randlett & Yu Hu & Ho Ko, 2023. "An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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