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Optically-controlled bacterial metabolite for cancer therapy

Author

Listed:
  • Di-Wei Zheng

    (Wuhan University)

  • Ying Chen

    (Wuhan University)

  • Zi-Hao Li

    (Wuhan University)

  • Lu Xu

    (Wuhan University)

  • Chu-Xin Li

    (Wuhan University)

  • Bin Li

    (Wuhan University)

  • Jin-Xuan Fan

    (Wuhan University)

  • Si-Xue Cheng

    (Wuhan University)

  • Xian-Zheng Zhang

    (Wuhan University)

Abstract

Bacteria preferentially accumulating in tumor microenvironments can be utilized as natural vehicles for tumor targeting. However, neither current chemical nor genetic approaches alone can fully satisfy the requirements on both stability and high efficiency. Here, we propose a strategy of “charging” bacteria with a nano-photocatalyst to strengthen their metabolic activities. Carbon nitride (C3N4) is combined with Escherichia coli (E. coli) carrying nitric oxide (NO) generation enzymes for photo-controlled bacterial metabolite therapy (PMT). Under light irradiation, photoelectrons produced by C3N4 can be transferred to E. coli to promote the enzymatic reduction of endogenous NO3– to cytotoxic NO with a 37-fold increase. In a mouse model, C3N4 loaded bacteria are perfectly accumulated throughout the tumor and the PMT treatment results in around 80% inhibition of tumor growth. Thus, synthetic materials-remodeled microorganism may be used to regulate focal microenvironments and increase therapeutic efficiency.

Suggested Citation

  • Di-Wei Zheng & Ying Chen & Zi-Hao Li & Lu Xu & Chu-Xin Li & Bin Li & Jin-Xuan Fan & Si-Xue Cheng & Xian-Zheng Zhang, 2018. "Optically-controlled bacterial metabolite for cancer therapy," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03233-9
    DOI: 10.1038/s41467-018-03233-9
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    Cited by:

    1. Yuhao Chen & Meng Du & Zhen Yuan & Zhiyi Chen & Fei Yan, 2022. "Spatiotemporal control of engineered bacteria to express interferon-γ by focused ultrasound for tumor immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Zhongmin Geng & Zhenping Cao & Rui Liu & Ke Liu & Jinyao Liu & Weihong Tan, 2021. "Aptamer-assisted tumor localization of bacteria for enhanced biotherapy," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Zhaokui Jin & Lingdong Jiang & Qianjun He, 2024. "Critical learning from industrial catalysis for nanocatalytic medicine," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Yulin Zhang & Kaiyan Xi & Zhipeng Fu & Yuying Zhang & Bo Cheng & Fan Feng & Yuanmin Dong & Zezheng Fang & Yi Zhang & Jianyu Shen & Mingrui Wang & Xu Han & Huimin Geng & Lei Sun & Xingang Li & Chen Che, 2024. "Stimulation of tumoricidal immunity via bacteriotherapy inhibits glioblastoma relapse," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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