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Sensory deprivation in Staphylococcus aureus

Author

Listed:
  • Maite Villanueva

    (UPNA-CSIC-Gobierno de Navarra)

  • Begoña García

    (UPNA-CSIC-Gobierno de Navarra
    IdiSNA)

  • Jaione Valle

    (UPNA-CSIC-Gobierno de Navarra
    IdiSNA)

  • Beatriz Rapún

    (UPNA-CSIC-Gobierno de Navarra
    IdiSNA)

  • Igor Ruiz de los Mozos

    (UPNA-CSIC-Gobierno de Navarra
    University College London Institute of Neurology)

  • Cristina Solano

    (UPNA-CSIC-Gobierno de Navarra
    IdiSNA)

  • Miguel Martí

    (Instituto de Biomedicina de Valencia (IBV-CSIC)
    Universidad Católica de Valencia San Vicente Mártir)

  • José R. Penadés

    (Instituto de Biomedicina de Valencia (IBV-CSIC)
    University of Glasgow)

  • Alejandro Toledo-Arana

    (UPNA-CSIC-Gobierno de Navarra)

  • Iñigo Lasa

    (UPNA-CSIC-Gobierno de Navarra
    IdiSNA)

Abstract

Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still survive under growth arrest conditions similarly to wild-type bacteria. Under replicating conditions, however, the WalRK system is necessary and sufficient to maintain bacterial growth, indicating that sensing through TCSs is mostly dispensable for living under constant environmental conditions. Characterization of S. aureus derivatives containing individual TCSs reveals that each TCS appears to be autonomous and self-sufficient to sense and respond to specific environmental cues, although some level of cross-regulation between non-cognate sensor-response regulator pairs occurs in vivo. This organization, if confirmed in other bacterial species, may provide a general evolutionarily mechanism for flexible bacterial adaptation to life in new niches.

Suggested Citation

  • Maite Villanueva & Begoña García & Jaione Valle & Beatriz Rapún & Igor Ruiz de los Mozos & Cristina Solano & Miguel Martí & José R. Penadés & Alejandro Toledo-Arana & Iñigo Lasa, 2018. "Sensory deprivation in Staphylococcus aureus," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02949-y
    DOI: 10.1038/s41467-018-02949-y
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    Cited by:

    1. Cosme Claverie & Francesco Coppolino & Maria-Vittoria Mazzuoli & Cécile Guyonnet & Elise Jacquemet & Rachel Legendre & Odile Sismeiro & Giuseppe Valerio Gaetano & Giuseppe Teti & Patrick Trieu-Cuot & , 2024. "Constitutive activation of two-component systems reveals regulatory network interactions in Streptococcus agalactiae," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Mais Maree & Le Thuy Nguyen & Ryosuke L. Ohniwa & Masato Higashide & Tarek Msadek & Kazuya Morikawa, 2022. "Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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