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The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

Author

Listed:
  • Irene Soncin

    (Nanyang Technological University, 60 Nanyang Drive)

  • Jianpeng Sheng

    (Nanyang Technological University, 60 Nanyang Drive)

  • Qi Chen

    (Nanyang Technological University, 60 Nanyang Drive)

  • Shihui Foo

    (Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove)

  • Kaibo Duan

    (Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove)

  • Josephine Lum

    (Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove)

  • Michael Poidinger

    (Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove)

  • Francesca Zolezzi

    (Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove
    GALDERMA R&D)

  • Klaus Karjalainen

    (Nanyang Technological University, 60 Nanyang Drive)

  • Christiane Ruedl

    (Nanyang Technological University, 60 Nanyang Drive)

Abstract

Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80hi cells. In colon adenomas of ApcMin/+ mice, F4/80hiMHCIIlow macrophages are not only preserved, but become the dominant subpopulation among tumour-resident macrophages during tumour progression. Furthermore, these pro-tumoural F4/80hiMHCIIlow and F4/80hiMHCIIhi macrophages can self-renew in the tumour and maintain their numbers mostly independent from bone marrow contribution. Analyses of colon adenomas indicate that CSF1 may be a key facilitator of macrophage self-renewal. In summary, the tumour microenvironment creates an isolated niche for tissue-resident macrophages that favours macrophage survival and self-renewal.

Suggested Citation

  • Irene Soncin & Jianpeng Sheng & Qi Chen & Shihui Foo & Kaibo Duan & Josephine Lum & Michael Poidinger & Francesca Zolezzi & Klaus Karjalainen & Christiane Ruedl, 2018. "The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02834-8
    DOI: 10.1038/s41467-018-02834-8
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    Cited by:

    1. Juan Du & Junlei Zhang & Lin Wang & Xun Wang & Yaxing Zhao & Jiaoying Lu & Tingmin Fan & Meng Niu & Jie Zhang & Fei Cheng & Jun Li & Qi Zhu & Daoqiang Zhang & Hao Pei & Guang Li & Xingguang Liang & He, 2023. "Selective oxidative protection leads to tissue topological changes orchestrated by macrophage during ulcerative colitis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Mokarram Hossain & Raymond Shim & Woo-Yong Lee & Arlene H. Sharpe & Paul Kubes, 2022. "Gata6+ resident peritoneal macrophages promote the growth of liver metastasis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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