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Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

Author

Listed:
  • Ralf Gilsbach

    (University of Freiburg)

  • Martin Schwaderer

    (University of Freiburg)

  • Sebastian Preissl

    (University of Freiburg)

  • Björn A. Grüning

    (University of Freiburg)

  • David Kranzhöfer

    (University of Freiburg)

  • Pedro Schneider

    (University of Freiburg)

  • Thomas G. Nührenberg

    (University of Freiburg
    University Heart Center Freiburg • Bad Krozingen)

  • Sonia Mulero-Navarro

    (Icahn School of Medicine at Mount Sinai)

  • Dieter Weichenhan

    (German Cancer Research Center (DKFZ))

  • Christian Braun

    (Ludwig-Maximilians-University)

  • Martina Dreßen

    (Technische Universität München
    Technische Universität München)

  • Adam R. Jacobs

    (Icahn School of Medicine at Mount Sinai)

  • Harald Lahm

    (Technische Universität München
    Technische Universität München)

  • Torsten Doenst

    (Friedrich-Schiller-University)

  • Rolf Backofen

    (University of Freiburg)

  • Markus Krane

    (Technische Universität München
    Technische Universität München
    DZHK (German Center for Cardiovascular Research) - Partner Site Munich Heart Alliance)

  • Bruce D. Gelb

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Lutz Hein

    (University of Freiburg
    University of Freiburg)

Abstract

Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. We find that prenatal development and postnatal maturation are characterized by a cooperation of active CpG methylation and histone marks at cis-regulatory and genic regions to shape the cardiac myocyte transcriptome. In contrast, pathological gene expression in terminal heart failure is accompanied by changes in active histone marks without major alterations in CpG methylation and repressive chromatin marks. Notably, cis-regulatory regions in cardiac myocytes are significantly enriched for cardiovascular disease-associated variants. This study uncovers distinct layers of epigenetic regulation not only during prenatal development and postnatal maturation but also in diseased human cardiac myocytes.

Suggested Citation

  • Ralf Gilsbach & Martin Schwaderer & Sebastian Preissl & Björn A. Grüning & David Kranzhöfer & Pedro Schneider & Thomas G. Nührenberg & Sonia Mulero-Navarro & Dieter Weichenhan & Christian Braun & Mart, 2018. "Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02762-z
    DOI: 10.1038/s41467-017-02762-z
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    Cited by:

    1. Lijun Wang & Jiaqi Wang & Pujiao Yu & Jingyi Feng & Gui-e Xu & Xuan Zhao & Tianhui Wang & H. Immo Lehmann & Guoping Li & Joost P. G. Sluijter & Junjie Xiao, 2022. "METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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