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Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Author

Listed:
  • Stanislaw Mitew

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne
    Monash University)

  • Ilan Gobius

    (The University of Queensland)

  • Laura R. Fenlon

    (The University of Queensland)

  • Stuart J. McDougall

    (The Florey Institute of Neuroscience and Mental Health)

  • David Hawkes

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne)

  • Yao Lulu Xing

    (The Florey Institute of Neuroscience and Mental Health
    Monash University)

  • Helena Bujalka

    (The University of Melbourne
    Oregon Health and Science University)

  • Andrew L. Gundlach

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne)

  • Linda J. Richards

    (The University of Queensland
    The University of Queensland)

  • Trevor J. Kilpatrick

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne)

  • Tobias D. Merson

    (The Florey Institute of Neuroscience and Mental Health
    Monash University
    The University of Melbourne)

  • Ben Emery

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne
    Oregon Health and Science University)

Abstract

Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capable of regulating myelination at the individual axon level is unclear. Here we demonstrate that stimulation of somatosensory axons in the mouse brain increases proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) within the underlying white matter. Stimulated axons display an increased probability of being myelinated compared to neighboring non-stimulated axons, in addition to being ensheathed with thicker myelin. Conversely, attenuating neuronal firing reduces axonal myelination in a selective activity-dependent manner. Our findings reveal that the process of selecting axons for myelination is strongly influenced by the relative activity of individual axons within a population. These observed cellular changes are consistent with the emerging concept that adaptive myelination is a key mechanism for the fine-tuning of neuronal circuitry in the mammalian CNS.

Suggested Citation

  • Stanislaw Mitew & Ilan Gobius & Laura R. Fenlon & Stuart J. McDougall & David Hawkes & Yao Lulu Xing & Helena Bujalka & Andrew L. Gundlach & Linda J. Richards & Trevor J. Kilpatrick & Tobias D. Merson, 2018. "Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02719-2
    DOI: 10.1038/s41467-017-02719-2
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    Cited by:

    1. Li-Pao Fang & Na Zhao & Laura C. Caudal & Hsin-Fang Chang & Renping Zhao & Ching-Hsin Lin & Nadine Hainz & Carola Meier & Bernhard Bettler & Wenhui Huang & Anja Scheller & Frank Kirchhoff & Xianshu Ba, 2022. "Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Takahiro Shimizu & Stuart G. Nayar & Matthew Swire & Yi Jiang & Matthew Grist & Malte Kaller & Cassandra Sampaio Baptista & David M. Bannerman & Heidi Johansen-Berg & Katsutoshi Ogasawara & Koujiro To, 2023. "Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Frederic Fiore & Khaleel Alhalaseh & Ram R. Dereddi & Felipe Bodaleo Torres & Ilknur Çoban & Ali Harb & Amit Agarwal, 2023. "Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    4. Xhoela Bame & Robert A. Hill, 2024. "Mitochondrial network reorganization and transient expansion during oligodendrocyte generation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    5. Chang Hoon Cho & Ilana Vasilisa Deyneko & Dylann Cordova-Martinez & Juan Vazquez & Anne S. Maguire & Jenny R. Diaz & Abigail U. Carbonell & Jaafar O. Tindi & Min-Hui Cui & Roman Fleysher & Sophie Molh, 2023. "ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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