IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-017-02719-2.html
   My bibliography  Save this article

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Author

Listed:
  • Stanislaw Mitew

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne
    Monash University)

  • Ilan Gobius

    (The University of Queensland)

  • Laura R. Fenlon

    (The University of Queensland)

  • Stuart J. McDougall

    (The Florey Institute of Neuroscience and Mental Health)

  • David Hawkes

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne)

  • Yao Lulu Xing

    (The Florey Institute of Neuroscience and Mental Health
    Monash University)

  • Helena Bujalka

    (The University of Melbourne
    Oregon Health and Science University)

  • Andrew L. Gundlach

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne)

  • Linda J. Richards

    (The University of Queensland
    The University of Queensland)

  • Trevor J. Kilpatrick

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne)

  • Tobias D. Merson

    (The Florey Institute of Neuroscience and Mental Health
    Monash University
    The University of Melbourne)

  • Ben Emery

    (The Florey Institute of Neuroscience and Mental Health
    The University of Melbourne
    Oregon Health and Science University)

Abstract

Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capable of regulating myelination at the individual axon level is unclear. Here we demonstrate that stimulation of somatosensory axons in the mouse brain increases proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) within the underlying white matter. Stimulated axons display an increased probability of being myelinated compared to neighboring non-stimulated axons, in addition to being ensheathed with thicker myelin. Conversely, attenuating neuronal firing reduces axonal myelination in a selective activity-dependent manner. Our findings reveal that the process of selecting axons for myelination is strongly influenced by the relative activity of individual axons within a population. These observed cellular changes are consistent with the emerging concept that adaptive myelination is a key mechanism for the fine-tuning of neuronal circuitry in the mammalian CNS.

Suggested Citation

  • Stanislaw Mitew & Ilan Gobius & Laura R. Fenlon & Stuart J. McDougall & David Hawkes & Yao Lulu Xing & Helena Bujalka & Andrew L. Gundlach & Linda J. Richards & Trevor J. Kilpatrick & Tobias D. Merson, 2018. "Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02719-2
    DOI: 10.1038/s41467-017-02719-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-02719-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-02719-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Li-Pao Fang & Na Zhao & Laura C. Caudal & Hsin-Fang Chang & Renping Zhao & Ching-Hsin Lin & Nadine Hainz & Carola Meier & Bernhard Bettler & Wenhui Huang & Anja Scheller & Frank Kirchhoff & Xianshu Ba, 2022. "Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Takahiro Shimizu & Stuart G. Nayar & Matthew Swire & Yi Jiang & Matthew Grist & Malte Kaller & Cassandra Sampaio Baptista & David M. Bannerman & Heidi Johansen-Berg & Katsutoshi Ogasawara & Koujiro To, 2023. "Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Frederic Fiore & Khaleel Alhalaseh & Ram R. Dereddi & Felipe Bodaleo Torres & Ilknur Çoban & Ali Harb & Amit Agarwal, 2023. "Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    4. Chang Hoon Cho & Ilana Vasilisa Deyneko & Dylann Cordova-Martinez & Juan Vazquez & Anne S. Maguire & Jenny R. Diaz & Abigail U. Carbonell & Jaafar O. Tindi & Min-Hui Cui & Roman Fleysher & Sophie Molh, 2023. "ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02719-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.